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20231227124008.0 |
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cr uuu---uuuuu |
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231223s2009 xx |||||o 00| ||eng c |
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|a 10.1111/j.1469-8137.2008.02642.x
|2 doi
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|a pubmed24n1222.xml
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|a (DE-627)NLM18512206X
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|a (NLM)19076721
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Gan, Yunzhe
|e verfasserin
|4 aut
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| 245 |
1 |
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|a The LCB2 subunit of the sphingolip biosynthesis enzyme serine palmitoyltransferase can function as an attenuator of the hypersensitive response and Bax-induced cell death
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|c 2009
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 06.02.2009
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|a Date Revised 13.12.2023
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|a published: Print
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|a Citation Status MEDLINE
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|a Previous results showed that expression of the gene encoding the LONG-CHAIN BASE2 (LCB(2)) subunit of serine palmitoyltransferase (SPT), designated BcLCB(2), from nonheading Chinese cabbage (Brassica campestris ssp. chinensis) was up-regulated during hypersensitive cell death (HCD) induced by the Phytophthora boehmeriae elicitor PB90. Overexpression of BcLCB(2) in Nicotiana tabacum leaves suppressed the HCD normally initiated by elicitors and PB90-triggered H(2)O(2) accumulation. BcLCB(2) also functioned as a suppressor of mouse Bcl-2 associated X (Bax) protein-mediated HCD and cell death caused by Ralstonia solanacearum. BcLCB(2) overexpression suppressed Bax- and oxidant stress-triggered yeast cell death. Reactive oxygen species (ROS) accumulation induced by Bax was compromised in BcLCB(2)-overexpressing yeast cells. The findings that NbLCB(2) silencing in Nicotiana benthamiana enhanced elicitor-triggered HCD, combined with the fact that myriocin, a potent inhibitor of SPT, had no effect on Bax-induced programmed cell death, suggested that suppression of cell death was not involved in the dominant-negative effect that resulted from BcLCB(2) overexpression. A BcLCB(2) mutant assay showed that the suppression was not involved in SPT activity. The results suggest that plant HCD and stress-induced yeast cell death might share a common signal transduction pathway involving LCB(2), and that LCB(2) protects against cell death by inhibiting ROS accumulation, this inhibition being independent of SPT activity
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Bacterial Outer Membrane Proteins
|2 NLM
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| 650 |
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|a Plant Proteins
|2 NLM
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| 650 |
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|a Protein Subunits
|2 NLM
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| 650 |
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|a harpin protein, Erwinia amylovora
|2 NLM
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| 650 |
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|a pathogenesis-related proteins, plant
|2 NLM
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| 650 |
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|a Serine C-Palmitoyltransferase
|2 NLM
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| 650 |
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7 |
|a EC 2.3.1.50
|2 NLM
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| 700 |
1 |
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|a Zhang, Lisha
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Zhengguang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dong, Suomeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Jun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Yuanchao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Xiaobo
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t The New phytologist
|d 1979
|g 181(2009), 1 vom: 23., Seite 127-146
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnns
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| 773 |
1 |
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|g volume:181
|g year:2009
|g number:1
|g day:23
|g pages:127-146
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| 856 |
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|u http://dx.doi.org/10.1111/j.1469-8137.2008.02642.x
|3 Volltext
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|d 181
|j 2009
|e 1
|b 23
|h 127-146
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