|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM184221935 |
| 003 |
DE-627 |
| 005 |
20231223170202.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231223s2009 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1016/j.clim.2008.08.030
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n0614.xml
|
| 035 |
|
|
|a (DE-627)NLM184221935
|
| 035 |
|
|
|a (NLM)18977698
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Montes, Monica
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells
|
| 264 |
|
1 |
|c 2009
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 27.01.2009
|
| 500 |
|
|
|a Date Revised 21.03.2022
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a ErratumIn: Clin Immunol. 2022 Apr;237:108967. - PMID 35307286
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a In this study, acute and chronic brain and spinal cord lesions, and normal appearing white matter (NAWM), were resected post-mortem from a patient with aggressive relapsing-remitting multiple sclerosis (MS). T-cell infiltrates from the central nervous system (CNS) lesions and NAWM were separated and characterized in-vitro. All infiltrates showed a proliferative response against multiple myelin peptides. Studies of the T-cell receptor (TCR)Vbeta and Jbeta usage revealed a very skewed repertoire with shared complementarity-determining region (CDR)3 lengths detected in all CNS lesions and NAWM. In the acute lesion, genomic profiling of the infiltrating T-cells revealed up-regulated expression of TCRalpha and beta chain, retinoic acid-related orphan nuclear hormone receptor C (RORC) transcription factor, and multiple cytokine genes that mediate Th17 cell expansion. The differentially expressed genes involved in regulation of Th17 cells represent promising targets for new therapies of relapsing-remitting MS
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, N.I.H., Extramural
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
7 |
|a Interleukin-17
|2 NLM
|
| 650 |
|
7 |
|a Receptors, Antigen, T-Cell, alpha-beta
|2 NLM
|
| 650 |
|
7 |
|a Receptors, Cytokine
|2 NLM
|
| 650 |
|
7 |
|a Transcription Factors
|2 NLM
|
| 700 |
1 |
|
|a Zhang, Xin
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Berthelot, Laureline
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Laplaud, David-Axel
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Brouard, Sophie
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Jin, Jianping
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Rogan, Sarah
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Armao, Diane
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Jewells, Valerie
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Soulillou, Jean-Paul
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Markovic-Plese, Silva
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 130(2009), 2 vom: 09. Feb., Seite 133-44
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
|
| 773 |
1 |
8 |
|g volume:130
|g year:2009
|g number:2
|g day:09
|g month:02
|g pages:133-44
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2008.08.030
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 130
|j 2009
|e 2
|b 09
|c 02
|h 133-44
|