Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells

Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells

In this study, acute and chronic brain and spinal cord lesions, and normal appearing white matter (NAWM), were resected post-mortem from a patient with aggressive relapsing-remitting multiple sclerosis (MS). T-cell infiltrates from the central nervous system (CNS) lesions and NAWM were separated and...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 130(2009), 2 vom: 09. Feb., Seite 133-44
1. Verfasser: Montes, Monica (VerfasserIn)
Weitere Verfasser: Zhang, Xin, Berthelot, Laureline, Laplaud, David-Axel, Brouard, Sophie, Jin, Jianping, Rogan, Sarah, Armao, Diane, Jewells, Valerie, Soulillou, Jean-Paul, Markovic-Plese, Silva
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2009
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Interleukin-17 Receptors, Antigen, T-Cell, alpha-beta Receptors, Cytokine Transcription Factors
Beschreibung
Zusammenfassung:In this study, acute and chronic brain and spinal cord lesions, and normal appearing white matter (NAWM), were resected post-mortem from a patient with aggressive relapsing-remitting multiple sclerosis (MS). T-cell infiltrates from the central nervous system (CNS) lesions and NAWM were separated and characterized in-vitro. All infiltrates showed a proliferative response against multiple myelin peptides. Studies of the T-cell receptor (TCR)Vbeta and Jbeta usage revealed a very skewed repertoire with shared complementarity-determining region (CDR)3 lengths detected in all CNS lesions and NAWM. In the acute lesion, genomic profiling of the infiltrating T-cells revealed up-regulated expression of TCRalpha and beta chain, retinoic acid-related orphan nuclear hormone receptor C (RORC) transcription factor, and multiple cytokine genes that mediate Th17 cell expansion. The differentially expressed genes involved in regulation of Th17 cells represent promising targets for new therapies of relapsing-remitting MS
Beschreibung:Date Completed 27.01.2009
Date Revised 21.03.2022
published: Print-Electronic
ErratumIn: Clin Immunol. 2022 Apr;237:108967. - PMID 35307286
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2008.08.030