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231223s2008 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2008.08.002
|2 doi
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|a pubmed24n0610.xml
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|a (DE-627)NLM182837378
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|a (NLM)18835223
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Speckmann, C
|e verfasserin
|4 aut
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| 245 |
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|a Reduced memory B cells in patients with hyper IgE syndrome
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|c 2008
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 04.12.2008
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|a Date Revised 21.11.2013
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Dominant-negative mutations in STAT-3 have recently been found in the majority of patients with sporadic or autosomal-dominant hyper IgE syndrome (HIES). Since STAT-3 plays a role in B cell development and differentiation, we analyzed memory B cells in 20 patients with HIES, 17 of which had STAT-3 mutations. All but four patients had reduced non-switched and/or class-switched memory B cells. No reduction in these B cell populations was found in 16 atopic dermatitis patients with IgE levels above 1000 KU/L. There was no correlation between the reduction of memory B cells and the ability to produce specific antibodies. Moreover, there was no correlation between the percentage of memory B cells and the infection history. Analysis of memory B cells can be useful in distinguishing patients with suspected HIES from patients with atopic disease, but probably fails to identify patients who are at high risk of infection
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|a Journal Article
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|a Multicenter Study
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|a Research Support, Non-U.S. Gov't
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|a Antibodies, Viral
|2 NLM
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|a STAT3 Transcription Factor
|2 NLM
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|a Immunoglobulin E
|2 NLM
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|a 37341-29-0
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|a DNA
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|a 9007-49-2
|2 NLM
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|a Enders, A
|e verfasserin
|4 aut
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|a Woellner, C
|e verfasserin
|4 aut
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|a Thiel, D
|e verfasserin
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|a Rensing-Ehl, A
|e verfasserin
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|a Schlesier, M
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|a Rohr, J
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|a Jakob, T
|e verfasserin
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|a Oswald, E
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|a Kopp, M V
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|a Sanal, O
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|a Litzman, J
|e verfasserin
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|a Plebani, A
|e verfasserin
|4 aut
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|a Pietrogrande, M C
|e verfasserin
|4 aut
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|a Franco, J L
|e verfasserin
|4 aut
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|a Espanol, T
|e verfasserin
|4 aut
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|a Grimbacher, B
|e verfasserin
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|a Ehl, S
|e verfasserin
|4 aut
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 129(2008), 3 vom: 17. Dez., Seite 448-54
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:129
|g year:2008
|g number:3
|g day:17
|g month:12
|g pages:448-54
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|u http://dx.doi.org/10.1016/j.clim.2008.08.002
|3 Volltext
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