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01000naa a22002652 4500 |
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NLM18269285X |
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DE-627 |
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cr uuu---uuuuu |
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231223s2009 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1016/j.clim.2008.08.011
|2 doi
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| 028 |
5 |
2 |
|a pubmed24n0609.xml
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|a (DE-627)NLM18269285X
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|a (NLM)18819842
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Sutterwala, Fayyaz S
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a NLRC4/IPAF
|b a CARD carrying member of the NLR family
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| 264 |
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1 |
|c 2009
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
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|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 14.01.2009
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| 500 |
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|a Date Revised 13.11.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a The NOD-like receptor (NLR) family of proteins is involved in the regulation of innate immune responses and cell death pathways. Recent findings show that the NLR family member NLRC4 (also known as IPAF) has important roles in innate immune responses to Gram-negative bacteria. Macrophages infected with Legionella pneumophila, Salmonella typhimurium, Shigella flexneri, or Pseudomonas aeruginosa activate caspase-1 in an NLRC4-dependent manner leading to macrophage cell death and the release of proinflammatory cytokines. This review will discuss these findings as well as the role of bacterial type III and type IV secretion systems and flagellin in NLRC4-mediated caspase-1 activation
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| 650 |
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|a Journal Article
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| 650 |
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Review
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| 650 |
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|a CARD Signaling Adaptor Proteins
|2 NLM
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| 650 |
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7 |
|a Calcium-Binding Proteins
|2 NLM
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| 650 |
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7 |
|a Neuronal Apoptosis-Inhibitory Protein
|2 NLM
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| 650 |
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|a Caspase 1
|2 NLM
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| 650 |
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7 |
|a EC 3.4.22.36
|2 NLM
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| 700 |
1 |
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|a Flavell, Richard A
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 130(2009), 1 vom: 11. Jan., Seite 2-6
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:130
|g year:2009
|g number:1
|g day:11
|g month:01
|g pages:2-6
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| 856 |
4 |
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|u http://dx.doi.org/10.1016/j.clim.2008.08.011
|3 Volltext
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