NLRC4/IPAF : a CARD carrying member of the NLR family
The NOD-like receptor (NLR) family of proteins is involved in the regulation of innate immune responses and cell death pathways. Recent findings show that the NLR family member NLRC4 (also known as IPAF) has important roles in innate immune responses to Gram-negative bacteria. Macrophages infected w...
| Publié dans: | Clinical immunology (Orlando, Fla.). - 1999. - 130(2009), 1 vom: 11. Jan., Seite 2-6 |
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| Format: | Article en ligne |
| Langue: | English |
| Publié: |
2009
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| Accès à la collection: | Clinical immunology (Orlando, Fla.) |
| Sujets: | Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review CARD Signaling Adaptor Proteins Calcium-Binding Proteins Neuronal Apoptosis-Inhibitory Protein Caspase 1 EC 3.4.22.36 |
| Résumé: | The NOD-like receptor (NLR) family of proteins is involved in the regulation of innate immune responses and cell death pathways. Recent findings show that the NLR family member NLRC4 (also known as IPAF) has important roles in innate immune responses to Gram-negative bacteria. Macrophages infected with Legionella pneumophila, Salmonella typhimurium, Shigella flexneri, or Pseudomonas aeruginosa activate caspase-1 in an NLRC4-dependent manner leading to macrophage cell death and the release of proinflammatory cytokines. This review will discuss these findings as well as the role of bacterial type III and type IV secretion systems and flagellin in NLRC4-mediated caspase-1 activation |
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| Description: | Date Completed 14.01.2009 Date Revised 13.11.2018 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1521-7035 |
| DOI: | 10.1016/j.clim.2008.08.011 |