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20231223162331.0 |
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231223s2008 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2008.07.018
|2 doi
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|a pubmed24n0607.xml
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|a (DE-627)NLM182101819
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|a (NLM)18757245
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Wei, Xiaowei
|e verfasserin
|4 aut
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| 245 |
1 |
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|a The suppressive effect of triptolide on chronic colitis and TNF-alpha/TNFR2 signal pathway in interleukin-10 deficient mice
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|c 2008
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 06.11.2008
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|a Date Revised 15.11.2012
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Recent studies have suggested a critical role of TNFR2 signaling associated with NF-kappaB activation in the pathogenesis of Crohn's disease. Triptolide, an extract from Tripterygium wilfordii Hook, has both anti-immune and anti-inflammatory effects. In this study, we evaluated its possible therapeutic effects on colitis in interleukin-10 deficient mice, a murine model of Crohn's disease. Triptolide was administered to IL-10(-/-) mice intraperitoneally every other day for 8 weeks. The severity of colitis in IL-10(-/-) mice was obviously reduced after triptolide treatment, with a reduction in the numbers of CD4+ T cells and macrophages in lamina propria. Triptolide also significantly decreased the production of TNF-alpha and IFN-gamma in colon. Furthermore, triptolide suppressed TNFR2 expression and NF-kappaB activation in colon of IL-10(-/-) mice. These data suggested that triptolide could ameliorate Th1-mediated chronic colitis and disordered immune state in IL-10(-/-) mice. A possible mechanism could be inhibiting TNF-alpha/TNFR2 signal pathway
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Diterpenes
|2 NLM
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| 650 |
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7 |
|a Epoxy Compounds
|2 NLM
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| 650 |
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|a Immunosuppressive Agents
|2 NLM
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| 650 |
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|a NF-kappa B
|2 NLM
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| 650 |
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|a Phenanthrenes
|2 NLM
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| 650 |
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|a Receptors, Tumor Necrosis Factor, Type II
|2 NLM
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| 650 |
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|a Tumor Necrosis Factor-alpha
|2 NLM
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| 650 |
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|a Interleukin-10
|2 NLM
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| 650 |
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7 |
|a 130068-27-8
|2 NLM
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| 650 |
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7 |
|a triptolide
|2 NLM
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| 650 |
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7 |
|a 19ALD1S53J
|2 NLM
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| 700 |
1 |
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|a Gong, Jianfeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhu, Juan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Pengfei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Ning
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhu, Weiming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Jieshou
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 129(2008), 2 vom: 04. Nov., Seite 211-8
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:129
|g year:2008
|g number:2
|g day:04
|g month:11
|g pages:211-8
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2008.07.018
|3 Volltext
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|d 129
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