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cr uuu---uuuuu |
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231223s2008 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2008.07.011
|2 doi
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|a pubmed24n0606.xml
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|a (DE-627)NLM181634104
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|a (NLM)18708297
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Vyshkina, Tamara
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Association of common mitochondrial DNA variants with multiple sclerosis and systemic lupus erythematosus
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|c 2008
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 07.10.2008
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|a Date Revised 20.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Mitochondrial dysfunction has been implicated in the pathogenesis of multiple sclerosis (MS) and systemic lupus erythematosus (SLE). This study re-investigates the roles of previously suggested candidate genes of energy metabolism (Complex I genes located in the nucleus and in the mitochondria) in patients with MS relative to ethnically matched SLE patients and healthy controls. After stringent correction for multiple testing, we reproduce the association of the mitochondrial (mt)DNA haplotype K* with MS, but reject the importance of previously suggested borderline associations with nuclear genes of Complex I. In addition, we detect the association of common variants of the mitochondrial ND2 and ATP6 genes with both MS and SLE, which raises the possibility of a shared mitochondrial genetic background of these two autoimmune diseases
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Research Support, U.S. Gov't, Non-P.H.S.
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| 650 |
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|a Biomarkers
|2 NLM
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| 650 |
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|a DNA, Mitochondrial
|2 NLM
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| 650 |
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|a MT-ATP6 protein, human
|2 NLM
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| 650 |
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|a NADH Dehydrogenase
|2 NLM
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| 650 |
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|a EC 1.6.99.3
|2 NLM
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| 650 |
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|a NADH dehydrogenase subunit 2, human
|2 NLM
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|2 NLM
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| 650 |
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|a Mitochondrial Proton-Translocating ATPases
|2 NLM
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| 650 |
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7 |
|a EC 3.6.3.-
|2 NLM
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| 700 |
1 |
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|a Sylvester, Andrew
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sadiq, Saud
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bonilla, Eduardo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Canter, Jeff A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Perl, Andras
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kalman, Bernadette
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 129(2008), 1 vom: 04. Okt., Seite 31-5
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:129
|g year:2008
|g number:1
|g day:04
|g month:10
|g pages:31-5
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|u http://dx.doi.org/10.1016/j.clim.2008.07.011
|3 Volltext
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