Association of common mitochondrial DNA variants with multiple sclerosis and systemic lupus erythematosus

Association of common mitochondrial DNA variants with multiple sclerosis and systemic lupus erythematosus

Mitochondrial dysfunction has been implicated in the pathogenesis of multiple sclerosis (MS) and systemic lupus erythematosus (SLE). This study re-investigates the roles of previously suggested candidate genes of energy metabolism (Complex I genes located in the nucleus and in the mitochondria) in p...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 129(2008), 1 vom: 04. Okt., Seite 31-5
1. Verfasser: Vyshkina, Tamara (VerfasserIn)
Weitere Verfasser: Sylvester, Andrew, Sadiq, Saud, Bonilla, Eduardo, Canter, Jeff A, Perl, Andras, Kalman, Bernadette
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2008
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Biomarkers DNA, Mitochondrial MT-ATP6 protein, human NADH Dehydrogenase EC 1.6.99.3 NADH dehydrogenase subunit 2, human mehr... Mitochondrial Proton-Translocating ATPases EC 3.6.3.-
Beschreibung
Zusammenfassung:Mitochondrial dysfunction has been implicated in the pathogenesis of multiple sclerosis (MS) and systemic lupus erythematosus (SLE). This study re-investigates the roles of previously suggested candidate genes of energy metabolism (Complex I genes located in the nucleus and in the mitochondria) in patients with MS relative to ethnically matched SLE patients and healthy controls. After stringent correction for multiple testing, we reproduce the association of the mitochondrial (mt)DNA haplotype K* with MS, but reject the importance of previously suggested borderline associations with nuclear genes of Complex I. In addition, we detect the association of common variants of the mitochondrial ND2 and ATP6 genes with both MS and SLE, which raises the possibility of a shared mitochondrial genetic background of these two autoimmune diseases
Beschreibung:Date Completed 07.10.2008
Date Revised 20.10.2021
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2008.07.011