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231223s2008 xx |||||o 00| ||eng c |
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|a 10.1021/la801487f
|2 doi
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|a pubmed24n0604.xml
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|a (DE-627)NLM181314320
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|a (NLM)18672924
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Yang, Wei
|e verfasserin
|4 aut
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| 245 |
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|a Film thickness dependence of protein adsorption from blood serum and plasma onto poly(sulfobetaine)-grafted surfaces
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|c 2008
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 13.11.2008
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|a Date Revised 16.11.2017
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a In this work, we investigate protein adsorption from single protein solutions and complex media such as 100% blood serum and plasma onto poly(sulfobetaine methacrylate) (polySBMA)-grafted surfaces via atom transfer radical polymerization (ATRP) at varying film thicknesses. It is interesting to observe that protein adsorption exhibits a minimum at a medium film thickness. Results show that the surface with 62 nm polySBMA brushes presents the best nonfouling character in 100% blood serum and plasma although all of these surfaces are highly resistant to nonspecific protein adsorption from single fibrinogen and lysozyme solutions. Surface resistance to 100% blood serum or plasma is necessary for many applications from blood-contacting devices to drug delivery. This work provides a new in vitro evaluation standard for the application of biomaterials in vivo
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Research Support, U.S. Gov't, Non-P.H.S.
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|a Ions
|2 NLM
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|a Polymers
|2 NLM
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|a Proteins
|2 NLM
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|a Betaine
|2 NLM
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|a 3SCV180C9W
|2 NLM
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|a sulfobetaine
|2 NLM
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|a 8CVU22OCJW
|2 NLM
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|a Fibrinogen
|2 NLM
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|a 9001-32-5
|2 NLM
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|a Muramidase
|2 NLM
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|a EC 3.2.1.17
|2 NLM
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| 700 |
1 |
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|a Chen, Shengfu
|e verfasserin
|4 aut
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| 700 |
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|a Cheng, Gang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Vaisocherová, Hana
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xue, Hong
|e verfasserin
|4 aut
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| 700 |
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|a Li, Wei
|e verfasserin
|4 aut
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| 700 |
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|a Zhang, Jinli
|e verfasserin
|4 aut
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| 700 |
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|a Jiang, Shaoyi
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 24(2008), 17 vom: 02. Sept., Seite 9211-4
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:24
|g year:2008
|g number:17
|g day:02
|g month:09
|g pages:9211-4
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