|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM181221047 |
| 003 |
DE-627 |
| 005 |
20231223160849.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231223s2008 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1016/j.clim.2008.06.008
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n0604.xml
|
| 035 |
|
|
|a (DE-627)NLM181221047
|
| 035 |
|
|
|a (NLM)18662895
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Tarrant, Teresa K
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN)
|
| 264 |
|
1 |
|c 2008
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 07.10.2008
|
| 500 |
|
|
|a Date Revised 20.10.2021
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a OBJECTIVE: Chemokine receptors are G-protein coupled receptors (GPCRs) phosphorylated by G-protein receptor kinases (GRKs) after ligand-mediated activation. We hypothesized that GRK subtypes differentially regulate granulocyte chemotaxis and clinical disease expression in the K/BxN model
|
| 520 |
|
|
|a METHODS: Clinical, histologic, and cytokine responses in GRK6-/-, GRK5-/-, GRK2+/-, and wildtype mice were evaluated using K/BxN serum transfer. Granulocyte chemotaxis was analyzed by transendothelial migration assays
|
| 520 |
|
|
|a RESULTS: Both GRK6-/- and GRK2+/- mice had increased arthritis disease severity (p<0.001); whereas GRK5-/- was not different from controls. Acute weight loss was enhanced in GRK6-/- and GRK2+/- mice (p<0.001, days 3-10). However, GRK6-/- mice uniquely had more weight loss (>10%), elevated serum IL-6, and enhanced migration toward LTB4 and C5a in vitro
|
| 520 |
|
|
|a CONCLUSIONS: GRK6 and -2, but not GRK5, are involved in the pathogenesis of acute arthritis in the K/BxN model. In particular, GRK6 may dampen inflammatory responses by regulating granulocyte trafficking toward chemoattractants
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, N.I.H., Extramural
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
7 |
|a Interleukin-6
|2 NLM
|
| 650 |
|
7 |
|a Leukotriene B4
|2 NLM
|
| 650 |
|
7 |
|a 1HGW4DR56D
|2 NLM
|
| 650 |
|
7 |
|a Complement C5a
|2 NLM
|
| 650 |
|
7 |
|a 80295-54-1
|2 NLM
|
| 650 |
|
7 |
|a GRK2 protein, mouse
|2 NLM
|
| 650 |
|
7 |
|a EC 2.7.11.15
|2 NLM
|
| 650 |
|
7 |
|a G-Protein-Coupled Receptor Kinase 2
|2 NLM
|
| 650 |
|
7 |
|a EC 2.7.11.16
|2 NLM
|
| 650 |
|
7 |
|a G-Protein-Coupled Receptor Kinases
|2 NLM
|
| 650 |
|
7 |
|a EC 2.7.11.16
|2 NLM
|
| 650 |
|
7 |
|a G-protein-coupled receptor kinase 6
|2 NLM
|
| 650 |
|
7 |
|a EC 2.7.11.16
|2 NLM
|
| 700 |
1 |
|
|a Rampersad, Rishi R
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Esserman, Denise
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Rothlein, Lisa R
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Liu, Peng
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Premont, Richard T
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Lefkowitz, Robert J
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Lee, David M
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Patel, Dhavalkumar D
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 129(2008), 1 vom: 18. Okt., Seite 115-22
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
|
| 773 |
1 |
8 |
|g volume:129
|g year:2008
|g number:1
|g day:18
|g month:10
|g pages:115-22
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2008.06.008
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 129
|j 2008
|e 1
|b 18
|c 10
|h 115-22
|