Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN)

OBJECTIVE: Chemokine receptors are G-protein coupled receptors (GPCRs) phosphorylated by G-protein receptor kinases (GRKs) after ligand-mediated activation. We hypothesized that GRK subtypes differentially regulate granulocyte chemotaxis and clinical disease expression in the K/BxN model

Détails bibliographiques
Publié dans:Clinical immunology (Orlando, Fla.). - 1999. - 129(2008), 1 vom: 15. Okt., Seite 115-22
Auteur principal: Tarrant, Teresa K (Auteur)
Autres auteurs: Rampersad, Rishi R, Esserman, Denise, Rothlein, Lisa R, Liu, Peng, Premont, Richard T, Lefkowitz, Robert J, Lee, David M, Patel, Dhavalkumar D
Format: Article en ligne
Langue:English
Publié: 2008
Accès à la collection:Clinical immunology (Orlando, Fla.)
Sujets:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Interleukin-6 Leukotriene B4 1HGW4DR56D Complement C5a 80295-54-1 GRK2 protein, mouse EC 2.7.11.15 plus... G-Protein-Coupled Receptor Kinase 2 EC 2.7.11.16 G-Protein-Coupled Receptor Kinases G-protein-coupled receptor kinase 6