Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN)

OBJECTIVE: Chemokine receptors are G-protein coupled receptors (GPCRs) phosphorylated by G-protein receptor kinases (GRKs) after ligand-mediated activation. We hypothesized that GRK subtypes differentially regulate granulocyte chemotaxis and clinical disease expression in the K/BxN model

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 129(2008), 1 vom: 18. Okt., Seite 115-22
1. Verfasser: Tarrant, Teresa K (VerfasserIn)
Weitere Verfasser: Rampersad, Rishi R, Esserman, Denise, Rothlein, Lisa R, Liu, Peng, Premont, Richard T, Lefkowitz, Robert J, Lee, David M, Patel, Dhavalkumar D
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2008
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Interleukin-6 Leukotriene B4 1HGW4DR56D Complement C5a 80295-54-1 GRK2 protein, mouse EC 2.7.11.15 mehr... G-Protein-Coupled Receptor Kinase 2 EC 2.7.11.16 G-Protein-Coupled Receptor Kinases G-protein-coupled receptor kinase 6