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231223s2008 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2008.05.011
|2 doi
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|a pubmed24n0604.xml
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|a (DE-627)NLM18112100X
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|a (NLM)18650128
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Lin, Ying-Ju
|e verfasserin
|4 aut
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| 245 |
1 |
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|a G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan
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|c 2008
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 07.10.2008
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|a Date Revised 15.09.2008
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Interleukin-2 (IL-2), one of the crucial immunoregulatory cytokines required for T lymphocyte activation, plays an important role in autoimmune diseases. An IL-2 genetic G/T polymorphism (rs2069763) has been linked with multiple sclerosis and rheumatoid arthritis. We tested a hypothesis that this polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Han Chinese SLE patients and a healthy control group in Taiwan. Our results indicate (a) a significantly higher G allele frequency in SLE patients (P=1.91 x 10(-14); OR=3.94; 95% CI=2.74-5.66), (b) a significantly higher G allele frequency in SLE patients with antinuclear antibodies (ANA) (P=0.033; OR=4.21; 95% CI=1.01-17.51) and (c) a significantly lower G allele frequency in SLE patients with discoid rash (P=0.019; OR=0.41; 95% CI=0.19-0.88). Our results suggest that this polymorphism may be involved in the genetic background of Taiwanese SLE
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|a Journal Article
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Interleukin-2
|2 NLM
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| 700 |
1 |
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|a Wan, Lei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sheu, Jim Jinn-Chyuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Chung-Ming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lin, Cheng-Wen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lan, Yu-Ching
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lai, Chih-Ho
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hung, Chien-Hui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tsai, Yuhsin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tsai, Chang-Hai
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lin, Wei-Yong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Hsin-Ping
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lin, Ting-Hsu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Yu-Min
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tsai, Fuu-Jen
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 129(2008), 1 vom: 15. Okt., Seite 36-9
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|g volume:129
|g year:2008
|g number:1
|g day:15
|g month:10
|g pages:36-9
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|u http://dx.doi.org/10.1016/j.clim.2008.05.011
|3 Volltext
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