G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan

Interleukin-2 (IL-2), one of the crucial immunoregulatory cytokines required for T lymphocyte activation, plays an important role in autoimmune diseases. An IL-2 genetic G/T polymorphism (rs2069763) has been linked with multiple sclerosis and rheumatoid arthritis. We tested a hypothesis that this po...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 129(2008), 1 vom: 15. Okt., Seite 36-9
1. Verfasser: Lin, Ying-Ju (VerfasserIn)
Weitere Verfasser: Wan, Lei, Sheu, Jim Jinn-Chyuan, Huang, Chung-Ming, Lin, Cheng-Wen, Lan, Yu-Ching, Lai, Chih-Ho, Hung, Chien-Hui, Tsai, Yuhsin, Tsai, Chang-Hai, Lin, Wei-Yong, Liu, Hsin-Ping, Lin, Ting-Hsu, Huang, Yu-Min, Tsai, Fuu-Jen
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2008
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Interleukin-2
Beschreibung
Zusammenfassung:Interleukin-2 (IL-2), one of the crucial immunoregulatory cytokines required for T lymphocyte activation, plays an important role in autoimmune diseases. An IL-2 genetic G/T polymorphism (rs2069763) has been linked with multiple sclerosis and rheumatoid arthritis. We tested a hypothesis that this polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Han Chinese SLE patients and a healthy control group in Taiwan. Our results indicate (a) a significantly higher G allele frequency in SLE patients (P=1.91 x 10(-14); OR=3.94; 95% CI=2.74-5.66), (b) a significantly higher G allele frequency in SLE patients with antinuclear antibodies (ANA) (P=0.033; OR=4.21; 95% CI=1.01-17.51) and (c) a significantly lower G allele frequency in SLE patients with discoid rash (P=0.019; OR=0.41; 95% CI=0.19-0.88). Our results suggest that this polymorphism may be involved in the genetic background of Taiwanese SLE
Beschreibung:Date Completed 07.10.2008
Date Revised 15.09.2008
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2008.05.011