CC-4047 promotes Th1 cell differentiation and reprograms polarized human Th2 cells by enhancing transcription factor T-bet

The IMiDs immunomodulatory drugs are an expanding family of compounds under investigation in a broad range of diseases because they exhibit immunomodulatory and anti-tumorigenic properties. Although the molecular targets remain unidentified, the broad activity of select IMiDs immunomodulatory drugs...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 128(2008), 3 vom: 15. Sept., Seite 392-9
1. Verfasser: Xu, Weiming (VerfasserIn)
Weitere Verfasser: Celeridad, Maria, Sankar, Sabita, Webb, David R, Bennett, Brydon L
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2008
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article GATA3 Transcription Factor GATA3 protein, human Interleukin-2 Receptors, Antigen, T-Cell T-Box Domain Proteins T-box transcription factor TBX21 Tumor Necrosis Factor-alpha Thalidomide 4Z8R6ORS6L mehr... Interferon-gamma 82115-62-6 pomalidomide D2UX06XLB5