|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM180317563 |
| 003 |
DE-627 |
| 005 |
20231223155255.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231223s2008 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1021/la800500c
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n0601.xml
|
| 035 |
|
|
|a (DE-627)NLM180317563
|
| 035 |
|
|
|a (NLM)18564864
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Spoerke, Erik D
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Directing the polar organization of microtubules
|
| 264 |
|
1 |
|c 2008
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 15.08.2008
|
| 500 |
|
|
|a Date Revised 09.07.2008
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Microtubules (MTs) are polar protein filaments that participate in critical biological functions ranging from motor protein direction to coordination of chromosome separation during cell division. The effective facilitation of these processes, however, requires careful regulation of the polar orientation and spatial organization of the assembled MTs. We describe here an artificial approach to polar MT assembly that enables us to create three-dimensional polar-oriented synthetic microtubule organizing centers (POSMOCs). Utilizing engineered MT polymerization in concert with functionalized micro- and nanoscale particles, we demonstrate the controllable polar assembly of MTs into asters and the variations in aster structure determined by the interactions between the MTs and the functionalized organizing particles. Inspired by the aster-like form of biological structures such as centrosomes, these POSMOCs represent a key step toward replicating biology's complex materials assembly machinery
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
4 |
|a Research Support, U.S. Gov't, Non-P.H.S.
|
| 700 |
1 |
|
|a Bachand, George D
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Liu, Jun
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Sasaki, Darryl
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Bunker, Bruce C
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1999
|g 24(2008), 14 vom: 15. Juli, Seite 7039-43
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
|
| 773 |
1 |
8 |
|g volume:24
|g year:2008
|g number:14
|g day:15
|g month:07
|g pages:7039-43
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1021/la800500c
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_22
|
| 912 |
|
|
|a GBV_ILN_350
|
| 912 |
|
|
|a GBV_ILN_721
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 24
|j 2008
|e 14
|b 15
|c 07
|h 7039-43
|