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231223s2008 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2008.03.505
|2 doi
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|a pubmed24n0599.xml
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|a (DE-627)NLM179780581
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|a (NLM)18502180
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Guida, Giuseppe
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Clonal CD8+ TCR-Vbeta expanded populations with effector memory phenotype in Churg Strauss syndrome
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| 264 |
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|c 2008
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 15.07.2008
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|a Date Revised 19.11.2015
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Churg Strauss Syndrome (CSS) is a systemic vasculitis in which oligoclonal T cell expansions might be involved in the pathogenesis. Combined analysis of TCR-Vbeta expression profile by flow cytometry and of TCR gene rearrangement by heteroduplex PCR was used to detect and characterize T cell expansions in 8 CSS patients, 10 asthmatics and 42 healthy subjects. In all CSS patients one or two Vbeta families were expanded among CD8+ cells, with an effector memory phenotype apt to populate tissues and inflammatory sites. Heteroduplex PCR showed the presence of one or more clonal TCR rearrangements, which reveals monoclonal or oligoclonal T cells subpopulations. After purification with a Vbeta specific monoclonal antibody, each CD8+/Vbeta+ expanded family showed a single TCR rearrangement, clearly suggestive of monoclonality. All CD8+ expansions were detectable throughout the disease course. TCR-Vbeta expanded or deleted populations were not observed in asthmatic patients. Clonal CD8+/Vbeta+ T cell expansions might be useful as a disease marker
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| 650 |
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|a Journal Article
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| 650 |
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7 |
|a Biomarkers
|2 NLM
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| 650 |
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7 |
|a Receptors, Antigen, T-Cell, alpha-beta
|2 NLM
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| 700 |
1 |
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|a Vallario, Antonella
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Stella, Stefania
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Boita, Monica
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Circosta, Paola
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mariani, Sara
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Prato, Giuseppina
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Heffler, Enrico
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bergia, Roberta
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sottile, Antonino
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rolla, Giovanni
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cignetti, Alessandro
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 128(2008), 1 vom: 01. Juli, Seite 94-102
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:128
|g year:2008
|g number:1
|g day:01
|g month:07
|g pages:94-102
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2008.03.505
|3 Volltext
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|d 128
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|h 94-102
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