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231223s2008 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2008.03.506
|2 doi
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|a pubmed25n0598.xml
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|a (DE-627)NLM179270524
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|a (NLM)18448390
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Slot, Marjan C
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Immunoregulatory gene polymorphisms are associated with ANCA-related vasculitis
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| 264 |
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1 |
|c 2008
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 15.07.2008
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|a Date Revised 31.03.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a T cell activation is regulated by inhibitory molecules such as PD-1 and CTLA-4, whose expression may be affected by gene polymorphisms. Increased T cell activation is present in patients with ANCA-associated vasculitis (AAV). We investigated two single-nucleotide polymorphisms (SNPs) in PDCD1 and five polymorphisms in CTLA4 in 102 patients with AAV and 188 healthy controls (HC). The distributions of the PD-1.3 and PD-1.5 SNPs, and the distributions of the CTLA4 promoter polymorphisms -1722T/C, -1661A/G, -318 C/T, and the (AT)(n) microsatellite in the 3'-untranslated region of CTLA4, did not differ between patients and HC. However, the +49 G allele was significantly more often present in patients with AAV. Furthermore, the co-occurrence of the PD-1.5 T allele with CTLA4 +49 AA homozygosity (i.e., the absence of a G allele) was less often present in patients compared to HC. These genetic polymorphisms may lead to hyperreactivity of T cells and thus may contribute to the pathogenesis of AAV
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| 650 |
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|a Journal Article
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| 650 |
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7 |
|a Antibodies, Antineutrophil Cytoplasmic
|2 NLM
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| 650 |
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7 |
|a Antigens, CD
|2 NLM
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| 650 |
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7 |
|a Apoptosis Regulatory Proteins
|2 NLM
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| 650 |
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7 |
|a CTLA-4 Antigen
|2 NLM
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| 650 |
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|a CTLA4 protein, human
|2 NLM
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| 650 |
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|a PDCD1 protein, human
|2 NLM
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| 650 |
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7 |
|a Programmed Cell Death 1 Receptor
|2 NLM
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| 700 |
1 |
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|a Sokolowska, Milena G
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Savelkouls, Kim G
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Janssen, Rob G J H
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Damoiseaux, Jan G M C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tervaert, Jan Willem Cohen
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 128(2008), 1 vom: 15. Juli, Seite 39-45
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:128
|g year:2008
|g number:1
|g day:15
|g month:07
|g pages:39-45
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2008.03.506
|3 Volltext
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