Immunoregulatory gene polymorphisms are associated with ANCA-related vasculitis

T cell activation is regulated by inhibitory molecules such as PD-1 and CTLA-4, whose expression may be affected by gene polymorphisms. Increased T cell activation is present in patients with ANCA-associated vasculitis (AAV). We investigated two single-nucleotide polymorphisms (SNPs) in PDCD1 and fi...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 128(2008), 1 vom: 15. Juli, Seite 39-45
1. Verfasser:	Slot, Marjan C (VerfasserIn)
Weitere Verfasser:	Sokolowska, Milena G, Savelkouls, Kim G, Janssen, Rob G J H, Damoiseaux, Jan G M C, Tervaert, Jan Willem Cohen
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2008
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Antibodies, Antineutrophil Cytoplasmic Antigens, CD Apoptosis Regulatory Proteins CTLA-4 Antigen CTLA4 protein, human PDCD1 protein, human Programmed Cell Death 1 Receptor