Expansion of circulating NKG2D+ effector memory T-cells and expression of NKG2D-ligand MIC in granulomaous lesions in Wegener's granulomatosis

Expansion of circulating NKG2D+ effector memory T-cells and expression of NKG2D-ligand MIC in granulomaous lesions in Wegener's granulomatosis

Expansion of circulating CD28- T-cells reminiscent of effector memory T-cells (T(EM)) has been reported in Wegener's granulomatosis (WG) recently. To investigate the role of T(EM) in WG, we analyzed the expression of the activating NK-receptor NKG2D and its ligand MIC on circulating T(EM) and i...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 127(2008), 2 vom: 15. Mai, Seite 144-50
1. Verfasser: Capraru, Dorin (VerfasserIn)
Weitere Verfasser: Müller, Antje, Csernok, Elena, Gross, Wolfgang L, Holl-Ulrich, Konstanze, Northfield, John, Klenerman, Paul, Herlyn, Karen, Holle, Julia, Gottschlich, Stefan, Voswinkel, Jan, Spies, Thomas, Fagin, Ursula, Jabs, Wolfram J, Lamprecht, Peter
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2008
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't CD28 Antigens GPI-Linked Proteins Intercellular Signaling Peptides and Proteins Interleukin-15 KLRK1 protein, human NK Cell Lectin-Like Receptor Subfamily K Receptors, Immunologic Receptors, Natural Killer Cell mehr... ULBP2 protein, human Myeloblastin EC 3.4.21.76
Beschreibung
Zusammenfassung:Expansion of circulating CD28- T-cells reminiscent of effector memory T-cells (T(EM)) has been reported in Wegener's granulomatosis (WG) recently. To investigate the role of T(EM) in WG, we analyzed the expression of the activating NK-receptor NKG2D and its ligand MIC on circulating T(EM) and in granulomatous lesions, respectively. NKG2D was anomalously expressed and preferentially detected on circulating CD4+CD28- T(EM) in WG. Compared to healthy controls, T(EM) display a more activated phenotype potentially favoring unbalanced proinflammatory responses in WG. Cluster-like formations of "Wegener's autoantigen" PR3 were surrounded by NKG2D+ and NKG2D-ligand MIC+ cells in WG-granulomata, but not in disease controls. Further, IL-15 - known to drive T(EM) differentiation and proliferation--was also expressed in WG-granulomata. Thus, through acquisition of NK-like "innate" properties, IL-15 stimulated NKG2D+ T(EM) could interact with MIC+ cells within WG-granulomata, thereby sustaining inflammation and autoimmunity and promoting self-perpetuating pathology in WG
Beschreibung:Date Completed 24.06.2008
Date Revised 16.11.2017
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2007.12.004