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231223s2008 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1021/la702357a
|2 doi
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|a pubmed24n0589.xml
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|a (DE-627)NLM176782613
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|a (NLM)18186654
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Wong, Joyce Y
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Dynamics of membrane adhesion
|b the role of polyethylene glycol spacers, ligand-receptor bond strength, and rupture pathway
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| 264 |
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|c 2008
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
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|2 rdacarrier
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| 500 |
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|a Date Completed 07.05.2008
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|a Date Revised 01.12.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Biological adhesion typically occurs through discrete cross bridges between complementary molecules on adjacent membranes. Here we report quantitative measurements of the binding distance between a lipid membrane functionalized with ligands on flexible polymer tether chains and a second membrane bearing complementary receptors using the surface force apparatus technique. The binding distance is shown to increase as a function of polymer tether length. Upon separation, adhesive failure occurs not at the strong ligand-receptor bond but primarily through the mechanical pullout of cross-bridging polymer tethers from the membrane. We summarize these measurements of complementary membrane adhesion dynamics using an energy-state diagram that encompasses the energetics of the polymer tether, ligand-receptor bond strength, and number of cross bridges formed
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| 650 |
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|a Journal Article
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| 650 |
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|a Research Support, N.I.H., Extramural
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| 650 |
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|a Research Support, U.S. Gov't, Non-P.H.S.
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| 650 |
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|a Ligands
|2 NLM
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| 650 |
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|a Lipid Bilayers
|2 NLM
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| 650 |
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|a Phosphatidylethanolamines
|2 NLM
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| 650 |
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|a 1,2-distearoylphosphatidylethanolamine
|2 NLM
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| 650 |
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7 |
|a 1G4B5265CQ
|2 NLM
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| 650 |
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|a Polyethylene Glycols
|2 NLM
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| 650 |
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7 |
|a 3WJQ0SDW1A
|2 NLM
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| 650 |
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7 |
|a 1,2-dilauroylphosphatidylethanolamine
|2 NLM
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| 650 |
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7 |
|a 53695-34-4
|2 NLM
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| 650 |
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7 |
|a Biotin
|2 NLM
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| 650 |
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|a 6SO6U10H04
|2 NLM
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| 650 |
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|a Streptavidin
|2 NLM
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| 650 |
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|a 9013-20-1
|2 NLM
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| 700 |
1 |
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|a Kuhl, Tonya L
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 24(2008), 4 vom: 19. Feb., Seite 1225-31
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|x 1520-5827
|7 nnns
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| 773 |
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|g volume:24
|g year:2008
|g number:4
|g day:19
|g month:02
|g pages:1225-31
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| 856 |
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|u http://dx.doi.org/10.1021/la702357a
|3 Volltext
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