Unambiguous structural elucidation of base-modified purine nucleosides using NMR
Copyright (c) 2007 John Wiley & Sons, Ltd.
| Veröffentlicht in: | Magnetic resonance in chemistry : MRC. - 1985. - 46(2008), 1 vom: 01. Jan., Seite 1-8 |
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| Weitere Verfasser: | , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2008
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| Zugriff auf das übergeordnete Werk: | Magnetic resonance in chemistry : MRC |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't Carbohydrates Protons Purine Nucleosides Purine Nucleotides |
| Zusammenfassung: | Copyright (c) 2007 John Wiley & Sons, Ltd. A general and unambiguous approach has been developed for structural elucidation of modified purine nucleosides using NMR spectroscopy. Systematic assignment of proton and carbon signals of modified nucleosides was firmly established by COSY and the anomerism of the glycosidic linkage of synthetic nucleosides clearly elucidated by NOESY experiments. Characteristic properties of 15N-isotopic labelling at specific positions of nucleosides were also employed for structural studies. The reported approach is applicable to other modified nucleosides and nucleotides, as well as nucleobases |
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| Beschreibung: | Date Completed 25.04.2008 Date Revised 20.10.2021 published: Print Citation Status MEDLINE |
| ISSN: | 1097-458X |