Developmental changes of FOXP3-expressing CD4+CD25+ regulatory T cells and their impairment in patients with FOXP3 gene mutations

Developmental changes of FOXP3-expressing CD4+CD25+ regulatory T cells and their impairment in patients with FOXP3 gene mutations

FOXP3 is required for the generation and function of CD4(+)CD25(+) regulatory T (Treg) cells. To elucidate the biological role of Treg cells, we used a monoclonal anti-FOXP3 antibody to examine the frequencies of Treg cells during child development. The percentages of CD4(+)CD25(+)FOXP3(+) T cells w...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 125(2007), 3 vom: 01. Dez., Seite 237-46
1. Verfasser: Fuchizawa, Tatsuya (VerfasserIn)
Weitere Verfasser: Adachi, Yuichi, Ito, Yasunori, Higashiyama, Hiroyuki, Kanegane, Hirokazu, Futatani, Takeshi, Kobayashi, Ichiro, Kamachi, Yoshiro, Sakamoto, Tatsuo, Tsuge, Ikuya, Tanaka, Hiroshi, Banham, Alison H, Ochs, Hans D, Miyawaki, Toshio
Format: Aufsatz
Sprache:English
Veröffentlicht: 2007
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't FOXP3 protein, human Forkhead Transcription Factors