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01000naa a22002652 4500 |
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NLM17419739X |
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DE-627 |
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20231223135409.0 |
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tu |
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231223s2008 xx ||||| 00| ||eng c |
| 028 |
5 |
2 |
|a pubmed24n0581.xml
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| 035 |
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|a (DE-627)NLM17419739X
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| 035 |
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|a (NLM)17916442
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| 040 |
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Boasso, Adriano
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Chronic innate immune activation as a cause of HIV-1 immunopathogenesis
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| 264 |
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1 |
|c 2008
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 02.04.2008
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| 500 |
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|a Date Revised 18.03.2022
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| 500 |
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|a published: Print-Electronic
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a Human immunodeficiency virus (HIV)-1 infection causes progressive impairment of the immune system in humans, characterized by depletion of CD4 T cells and loss of T cell function. Increased markers of T cell activation and lymphoid hyperplasia suggest that chronic T cell activation persists in immunocompromised hosts, and contributes to the exhaustion of immune functions. Here we propose a revision of this hypothesis, in which we suggest that chronic activation of innate immunity may negatively affect adaptive T cell-mediated responses. We hypothesize that constant exposure of the effector cells of innate immunity to HIV results in their chronic hyperactivation, with deleterious effects on T cells. In particular, plasmacytoid dendritic cells (pDC) may be highly susceptible to HIV-induced activation due to its interaction with the cellular receptor CD4, expressed by pDC. Subsequent production of type I interferon and indoleamine 2,3-dioxygenase may exert suppressive and cytotoxic effects on T cells
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Review
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| 700 |
1 |
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|a Shearer, Gene M
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 126(2008), 3 vom: 01. März, Seite 235-42
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:126
|g year:2008
|g number:3
|g day:01
|g month:03
|g pages:235-42
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
|
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 126
|j 2008
|e 3
|b 01
|c 03
|h 235-42
|