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|a (NLM)17867711
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|a DE-627
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|e rakwb
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|a eng
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|a Luijten, Jeroen
|e verfasserin
|4 aut
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|a Reversible helix sense inversion in surface-grafted poly(beta-phenethyl-L-aspartate) films
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|c 2007
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 13.11.2007
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|a Date Revised 02.10.2007
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a The reversible manipulation of the helix screw sense in surface-grafted poly(beta-phenethyl-L-aspartate) (PPELA) films by means of external stimuli was investigated. Ringopening polymerization of beta-phenethyl-L-aspartate N-carboxyanhydride initiated from primary amino-functionalized silicon and quartz substrates results in surface-grafted PPELA films in which the end-grafted polypeptide chains have a right-handed alpha-helical conformation. Upon annealing of the film at 150 degrees C for 30 min, a helix screw sense inversion takes place and the grafted chains adopt a left-handed pi-helical conformation. In the solid state, this left-handed pi-helical form is completely stable and cannot be changed by reheating and/or cooling. Upon immersion of the annealed grafted film in chloroform or other helicogenic solvents, the grafted polypeptide chains completely revert to their original right-handed alpha-helical form. Successive annealing and solvent treatment steps show that this helix sense inversion cycle can be repeated many times
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|a Journal Article
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|a Vorenkamp, Eltjo J
|e verfasserin
|4 aut
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|a Schouten, Arend J
|e verfasserin
|4 aut
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1999
|g 23(2007), 21 vom: 09. Okt., Seite 10772-8
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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|g volume:23
|g year:2007
|g number:21
|g day:09
|g month:10
|g pages:10772-8
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|d 23
|j 2007
|e 21
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|c 10
|h 10772-8
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