Reversible helix sense inversion in surface-grafted poly(beta-phenethyl-L-aspartate) films

The reversible manipulation of the helix screw sense in surface-grafted poly(beta-phenethyl-L-aspartate) (PPELA) films by means of external stimuli was investigated. Ringopening polymerization of beta-phenethyl-L-aspartate N-carboxyanhydride initiated from primary amino-functionalized silicon and qu...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1999. - 23(2007), 21 vom: 09. Okt., Seite 10772-8
1. Verfasser: Luijten, Jeroen (VerfasserIn)
Weitere Verfasser: Vorenkamp, Eltjo J, Schouten, Arend J
Format: Aufsatz
Sprache:English
Veröffentlicht: 2007
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article
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100 1 |a Luijten, Jeroen  |e verfasserin  |4 aut 
245 1 0 |a Reversible helix sense inversion in surface-grafted poly(beta-phenethyl-L-aspartate) films 
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520 |a The reversible manipulation of the helix screw sense in surface-grafted poly(beta-phenethyl-L-aspartate) (PPELA) films by means of external stimuli was investigated. Ringopening polymerization of beta-phenethyl-L-aspartate N-carboxyanhydride initiated from primary amino-functionalized silicon and quartz substrates results in surface-grafted PPELA films in which the end-grafted polypeptide chains have a right-handed alpha-helical conformation. Upon annealing of the film at 150 degrees C for 30 min, a helix screw sense inversion takes place and the grafted chains adopt a left-handed pi-helical conformation. In the solid state, this left-handed pi-helical form is completely stable and cannot be changed by reheating and/or cooling. Upon immersion of the annealed grafted film in chloroform or other helicogenic solvents, the grafted polypeptide chains completely revert to their original right-handed alpha-helical form. Successive annealing and solvent treatment steps show that this helix sense inversion cycle can be repeated many times 
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700 1 |a Schouten, Arend J  |e verfasserin  |4 aut 
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