Reversible helix sense inversion in surface-grafted poly(beta-phenethyl-L-aspartate) films
The reversible manipulation of the helix screw sense in surface-grafted poly(beta-phenethyl-L-aspartate) (PPELA) films by means of external stimuli was investigated. Ringopening polymerization of beta-phenethyl-L-aspartate N-carboxyanhydride initiated from primary amino-functionalized silicon and qu...
| Veröffentlicht in: | Langmuir : the ACS journal of surfaces and colloids. - 1999. - 23(2007), 21 vom: 09. Okt., Seite 10772-8 |
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| Weitere Verfasser: | , |
| Format: | Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2007
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| Zugriff auf das übergeordnete Werk: | Langmuir : the ACS journal of surfaces and colloids |
| Schlagworte: | Journal Article |
| Zusammenfassung: | The reversible manipulation of the helix screw sense in surface-grafted poly(beta-phenethyl-L-aspartate) (PPELA) films by means of external stimuli was investigated. Ringopening polymerization of beta-phenethyl-L-aspartate N-carboxyanhydride initiated from primary amino-functionalized silicon and quartz substrates results in surface-grafted PPELA films in which the end-grafted polypeptide chains have a right-handed alpha-helical conformation. Upon annealing of the film at 150 degrees C for 30 min, a helix screw sense inversion takes place and the grafted chains adopt a left-handed pi-helical conformation. In the solid state, this left-handed pi-helical form is completely stable and cannot be changed by reheating and/or cooling. Upon immersion of the annealed grafted film in chloroform or other helicogenic solvents, the grafted polypeptide chains completely revert to their original right-handed alpha-helical form. Successive annealing and solvent treatment steps show that this helix sense inversion cycle can be repeated many times |
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| Beschreibung: | Date Completed 13.11.2007 Date Revised 02.10.2007 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
| ISSN: | 1520-5827 |