Multifunctional layer-by-layer coating of digitally encoded microparticles

In the field of medical diagnostics there is a growing need for inexpensive, accurate, and quick "multiplexing" assays. By making use of encoded microparticles, such assays allow simultaneous determination of the presence of several analytes in a biological sample. The microparticles under...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1991. - 23(2007), 20 vom: 25. Sept., Seite 10272-9
1. Verfasser: Derveaux, Stefaan (VerfasserIn)
Weitere Verfasser: De Geest, Bruno G, Roelant, Chris, Braeckmans, Kevin, Demeester, Jo, De Smedt, Stefaan C
Format: Aufsatz
Sprache:English
Veröffentlicht: 2007
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article
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245 1 0 |a Multifunctional layer-by-layer coating of digitally encoded microparticles 
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520 |a In the field of medical diagnostics there is a growing need for inexpensive, accurate, and quick "multiplexing" assays. By making use of encoded microparticles, such assays allow simultaneous determination of the presence of several analytes in a biological sample. The microparticles under investigation in this study are encoded by writing a digital dot or bar code in their central plane. This study evaluates to what extent a "multifunctional" coating can be applied around the digitally encoded microparticles by the layer-by-layer (LbL) technology. We show that a LbL coating containing CrO2 nanoparticles allows (a) an optimal (optical) readout of the dot and bar codes, (b) a perfect orientation of the microparticles, necessary to be able to read the code, and (c) an optimal coupling of capture probes to the surface of the microparticles 
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700 1 |a De Geest, Bruno G  |e verfasserin  |4 aut 
700 1 |a Roelant, Chris  |e verfasserin  |4 aut 
700 1 |a Braeckmans, Kevin  |e verfasserin  |4 aut 
700 1 |a Demeester, Jo  |e verfasserin  |4 aut 
700 1 |a De Smedt, Stefaan C  |e verfasserin  |4 aut 
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