Multifunctional layer-by-layer coating of digitally encoded microparticles
In the field of medical diagnostics there is a growing need for inexpensive, accurate, and quick "multiplexing" assays. By making use of encoded microparticles, such assays allow simultaneous determination of the presence of several analytes in a biological sample. The microparticles under...
| Veröffentlicht in: | Langmuir : the ACS journal of surfaces and colloids. - 1991. - 23(2007), 20 vom: 25. Sept., Seite 10272-9 |
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| 1. Verfasser: | |
| Weitere Verfasser: | , , , , |
| Format: | Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2007
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| Zugriff auf das übergeordnete Werk: | Langmuir : the ACS journal of surfaces and colloids |
| Schlagworte: | Journal Article |
| Zusammenfassung: | In the field of medical diagnostics there is a growing need for inexpensive, accurate, and quick "multiplexing" assays. By making use of encoded microparticles, such assays allow simultaneous determination of the presence of several analytes in a biological sample. The microparticles under investigation in this study are encoded by writing a digital dot or bar code in their central plane. This study evaluates to what extent a "multifunctional" coating can be applied around the digitally encoded microparticles by the layer-by-layer (LbL) technology. We show that a LbL coating containing CrO2 nanoparticles allows (a) an optimal (optical) readout of the dot and bar codes, (b) a perfect orientation of the microparticles, necessary to be able to read the code, and (c) an optimal coupling of capture probes to the surface of the microparticles |
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| Beschreibung: | Date Completed 13.11.2007 Date Revised 18.09.2007 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 0743-7463 |