Syk kinase as a treatment target for therapy in autoimmune diseases
Spleen tyrosine kinase (Syk) associates with a variety of immunoreceptors in myeloid and lymphoid cells. Syk initiates intracellular signaling once the receptor is engaged by its ligand. Blocking Syk may prove beneficial in interrupting the propagation of the abnormal immune response in both autoimm...
| Publié dans: | Clinical immunology (Orlando, Fla.). - 1999. - 124(2007), 3 vom: 01. Sept., Seite 235-7 |
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| Format: | Article |
| Langue: | English |
| Publié: |
2007
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| Accès à la collection: | Clinical immunology (Orlando, Fla.) |
| Sujets: | Journal Article Comment Intracellular Signaling Peptides and Proteins Ligands Protein Kinase Inhibitors Receptors, IgG Protein-Tyrosine Kinases EC 2.7.10.1 SYK protein, human EC 2.7.10.2 |
| Résumé: | Spleen tyrosine kinase (Syk) associates with a variety of immunoreceptors in myeloid and lymphoid cells. Syk initiates intracellular signaling once the receptor is engaged by its ligand. Blocking Syk may prove beneficial in interrupting the propagation of the abnormal immune response in both autoimmune and allergic diseases |
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| Description: | Date Completed 25.10.2007 Date Revised 13.11.2018 published: Print-Electronic CommentOn: Clin Immunol. 2007 Sep;124(3):244-57. doi: 10.1016/j.clim.2007.03.543. - PMID 17537677 Citation Status MEDLINE |
| ISSN: | 1521-7035 |