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|a (DE-627)NLM171445848
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|a (NLM)17627892
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Frisullo, Giovanni
|e verfasserin
|4 aut
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| 245 |
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|a Glucocorticoid treatment reduces T-bet and pSTAT1 expression in mononuclear cells from relapsing remitting multiple sclerosis patients
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|c 2007
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 25.10.2007
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|a Date Revised 21.11.2013
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a High dose glucocorticoid (GC) treatment has been demonstrated to have a short-term beneficial effect on functional recovery in relapsing multiple sclerosis (MS) patients but the exact mechanism of action of GCs in MS is unclear. We found that high dose intravenous GCs strongly reduced T-bet and pSTAT1 expression in CD4+, CD8+, CD14+ circulating cells in RRMS patients in relapse. pSTAT1and T-bet reduction was associated with the decline of IFNgamma production by PBMCs. A significant increase of AV-positive CD4+ and CD8+ T cells was detectable after GC treatment without any variation in the percentage of annexin V-positive monocytes. By in vitro analysis, patients during relapse, either before or after GC treatment, exhibited a lower proportion of apoptotic lymphocytes than remitting patients and controls. Our study suggests that GCs can modulate T-bet and STAT1 expression and that IFNgamma signalling inhibition contributes to anti-inflammatory action of GCs in the treatment of relapses of MS patients
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Annexin A5
|2 NLM
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| 650 |
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|a Cytokines
|2 NLM
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| 650 |
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|a Glucocorticoids
|2 NLM
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| 650 |
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|a STAT1 Transcription Factor
|2 NLM
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| 650 |
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|a STAT3 Transcription Factor
|2 NLM
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|a T-Box Domain Proteins
|2 NLM
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|a T-box transcription factor TBX21
|2 NLM
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| 650 |
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|a Methylprednisolone
|2 NLM
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| 650 |
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|a X4W7ZR7023
|2 NLM
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| 700 |
1 |
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|a Nociti, Viviana
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Iorio, Raffaele
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Katia Patanella, Agata
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bianco, Assunta
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Caggiula, Marcella
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sancricca, Cristina
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tonali, Pietro Attilio
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mirabella, Massimiliano
|e verfasserin
|4 aut
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| 700 |
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|a Batocchi, Anna Paola
|e verfasserin
|4 aut
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| 773 |
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8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 124(2007), 3 vom: 04. Sept., Seite 284-93
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:124
|g year:2007
|g number:3
|g day:04
|g month:09
|g pages:284-93
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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| 912 |
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|a AR
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| 952 |
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|d 124
|j 2007
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|c 09
|h 284-93
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