Glucocorticoid treatment reduces T-bet and pSTAT1 expression in mononuclear cells from relapsing remitting multiple sclerosis patients

Glucocorticoid treatment reduces T-bet and pSTAT1 expression in mononuclear cells from relapsing remitting multiple sclerosis patients

High dose glucocorticoid (GC) treatment has been demonstrated to have a short-term beneficial effect on functional recovery in relapsing multiple sclerosis (MS) patients but the exact mechanism of action of GCs in MS is unclear. We found that high dose intravenous GCs strongly reduced T-bet and pSTA...

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Détails bibliographiques
Publié dans:Clinical immunology (Orlando, Fla.). - 1999. - 124(2007), 3 vom: 04. Sept., Seite 284-93
Auteur principal: Frisullo, Giovanni (Auteur)
Autres auteurs: Nociti, Viviana, Iorio, Raffaele, Katia Patanella, Agata, Bianco, Assunta, Caggiula, Marcella, Sancricca, Cristina, Tonali, Pietro Attilio, Mirabella, Massimiliano, Batocchi, Anna Paola
Format: Article
Langue:English
Publié: 2007
Accès à la collection:Clinical immunology (Orlando, Fla.)
Sujets:Journal Article Research Support, Non-U.S. Gov't Annexin A5 Cytokines Glucocorticoids STAT1 Transcription Factor STAT3 Transcription Factor T-Box Domain Proteins T-bet Transcription Factor Methylprednisolone X4W7ZR7023