Glucocorticoid treatment reduces T-bet and pSTAT1 expression in mononuclear cells from relapsing remitting multiple sclerosis patients

Glucocorticoid treatment reduces T-bet and pSTAT1 expression in mononuclear cells from relapsing remitting multiple sclerosis patients

High dose glucocorticoid (GC) treatment has been demonstrated to have a short-term beneficial effect on functional recovery in relapsing multiple sclerosis (MS) patients but the exact mechanism of action of GCs in MS is unclear. We found that high dose intravenous GCs strongly reduced T-bet and pSTA...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 124(2007), 3 vom: 04. Sept., Seite 284-93
1. Verfasser: Frisullo, Giovanni (VerfasserIn)
Weitere Verfasser: Nociti, Viviana, Iorio, Raffaele, Katia Patanella, Agata, Bianco, Assunta, Caggiula, Marcella, Sancricca, Cristina, Tonali, Pietro Attilio, Mirabella, Massimiliano, Batocchi, Anna Paola
Format: Aufsatz
Sprache:English
Veröffentlicht: 2007
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Annexin A5 Cytokines Glucocorticoids STAT1 Transcription Factor STAT3 Transcription Factor T-Box Domain Proteins T-box transcription factor TBX21 Methylprednisolone X4W7ZR7023