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231223s2006 xx ||||| 00| ||eng c |
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Nieh, Mu-Ping
|e verfasserin
|4 aut
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| 245 |
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|a Spontaneously forming ellipsoidal phospholipid unilamellar vesicles and their interactions with helical domains of saposin C
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|c 2006
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|b nc
|2 rdacarrier
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|a Date Completed 26.01.2007
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|a Date Revised 03.12.2007
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|a published: Print
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|a Citation Status MEDLINE
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|a We have observed a bimodal distribution of ellipsoidal unilamellar vesicles (ULVs) in a phospholipid mixture composed of dioleoyl phosphatidylserine (DOPS) and dipalmitoyl and dihexanoyl phosphatidylcholine, DPPC and DHPC, respectively. Dynamic light scattering and transmission electron microscopy data indicate a bimodal size distribution of these nanoparticles with hydrodynamic radii of approximately 200 and >500 nm, while small-angle neutron scattering data were fit using a model of coexisting monodisperse morphologies, namely, oblate and triaxial ellipsoidal vesicles. Unlike DOPS ULV formed by sonication, which can fuse days after being formed, these ULVs are stable over a period of 12 months at 4 degrees C. We also report on the structure of these ULVs associated with the two helical peptide domains (H1 and H2) of a glucosylprotein, namely, Saposin C, to gain some insight into protein-membrane interactions
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Research Support, U.S. Gov't, Non-P.H.S.
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| 650 |
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|a Phospholipids
|2 NLM
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| 650 |
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|a Saposins
|2 NLM
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| 650 |
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|a Unilamellar Liposomes
|2 NLM
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| 700 |
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|a Pencer, Jeremy
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Katsaras, John
|e verfasserin
|4 aut
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| 700 |
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|a Qi, Xiaoyang
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 22(2006), 26 vom: 19. Dez., Seite 11028-33
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:22
|g year:2006
|g number:26
|g day:19
|g month:12
|g pages:11028-33
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