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01000caa a22002652 4500 |
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NLM166260983 |
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DE-627 |
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20250207175458.0 |
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tu |
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231223s2007 xx ||||| 00| ||eng c |
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2 |
|a pubmed25n0554.xml
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|a (DE-627)NLM166260983
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|a (NLM)17070108
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Zhang, Ai-Hua
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Inhibition of oxidation activity of myeloperoxidase (MPO) by propylthiouracil (PTU) and anti-MPO antibodies from patients with PTU-induced vasculitis
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| 264 |
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1 |
|c 2007
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 07.03.2007
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| 500 |
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|a Date Revised 20.11.2014
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| 500 |
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Propylthiouracil (PTU) could induce antineutrophil cytoplasmic antibody (ANCA) associated vasculitis. This study aimed to investigate the inhibitory effects on MPO oxidation activity by PTU and MPO-ANCA from patients with primary microscopic polyangiitis (MPA) and PTU-induced vasculitis. IgG preparations were purified from MPO-ANCA-positive sera from seven patients with PTU-induced vasculitis and ten patients with primary MPA. The oxidation activity of MPO was measured in the presence of PTU and MPO-ANCA-positive IgG preparations from patients with PTU-induced vasculitis and primary MPA respectively. PTU could competitively inhibit the oxidation activity of MPO dose dependently. MPO-ANCA-positive IgG preparations from 6/7 patients with PTU-induced vasculitis and only 3/10 from patients with primary MPA could inhibit the MPO activity in a dose-dependent manner. In conclusions, the oxidation activity of MPO could be inhibited by PTU and PTU-induced MPO-ANCA in a dose-dependent manner, which might be involved in the pathogenesis PTU-induced vasculitis
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Antibodies, Antineutrophil Cytoplasmic
|2 NLM
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| 650 |
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7 |
|a Antimetabolites
|2 NLM
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| 650 |
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7 |
|a Propylthiouracil
|2 NLM
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| 650 |
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7 |
|a 721M9407IY
|2 NLM
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| 650 |
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7 |
|a Peroxidase
|2 NLM
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| 650 |
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7 |
|a EC 1.11.1.7
|2 NLM
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| 650 |
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7 |
|a Myeloblastin
|2 NLM
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| 650 |
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7 |
|a EC 3.4.21.76
|2 NLM
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| 700 |
1 |
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|a Chen, Min
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gao, Ying
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Ming-Hui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Hai-Yan
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 122(2007), 2 vom: 01. Feb., Seite 187-93
|w (DE-627)NLM098196855
|x 1521-6616
|7 nnns
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| 773 |
1 |
8 |
|g volume:122
|g year:2007
|g number:2
|g day:01
|g month:02
|g pages:187-93
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 122
|j 2007
|e 2
|b 01
|c 02
|h 187-93
|