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231223s2006 xx ||||| 00| ||eng c |
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|a pubmed24n0550.xml
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|a (DE-627)NLM164904530
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|a (NLM)16922522
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Taboada, Pablo
|e verfasserin
|4 aut
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|a Micellization and drug solubilization in aqueous solutions of a diblock copolymer of ethylene oxide and phenyl glycidyl ether
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|c 2006
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 21.09.2007
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|a Date Revised 19.11.2015
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|a published: Print
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|a Citation Status MEDLINE
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|a The aim of this study was to define a block copolymer micellar system with a high solubilization capacity for poorly soluble aromatic drugs. Ethylene oxide and phenyl glycidyl ether were sequentially polymerized to form the diblock copolymer G5E67 (G = phenyl glycidyl ether, OCH2CH(CH2OC6H5); E = oxyethylene, OCH2CH2; subscripts denote number-average block lengths in repeat units). The association properties in aqueous solution over the range 20-50 degrees C were investigated by surface tensiometry and light scattering, yielding values of the cmc, hydrodynamic radius, and association number; gel boundaries in concentrated micellar solution were investigated by tube inversion. The solubilization capacity of G5E67 for the poorly water-soluble drug griseofulvin was higher than that of a triblock EGE copolymer of longer G block length and considerably higher than that achieved with poloxamers (EmPnEm, P = oxypropylene)
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Gels
|2 NLM
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|a Micelles
|2 NLM
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|a Pharmaceutical Preparations
|2 NLM
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|a Phenyl Ethers
|2 NLM
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|a Polymers
|2 NLM
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|a Solutions
|2 NLM
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|a Water
|2 NLM
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|a 059QF0KO0R
|2 NLM
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|a phenylglycidyl ether
|2 NLM
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|a 44KJQ1655I
|2 NLM
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|a Ethylene Oxide
|2 NLM
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|a JJH7GNN18P
|2 NLM
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|a Velasquez, Gemma
|e verfasserin
|4 aut
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|a Barbosa, Silvia
|e verfasserin
|4 aut
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| 700 |
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|a Yang, Zhuo
|e verfasserin
|4 aut
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|a Nixon, S Keith
|e verfasserin
|4 aut
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|a Zhou, Zhengyuan
|e verfasserin
|4 aut
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|a Heatley, Frank
|e verfasserin
|4 aut
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|a Ashford, Marianne
|e verfasserin
|4 aut
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|a Mosquera, Victor
|e verfasserin
|4 aut
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|a Attwood, David
|e verfasserin
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|a Booth, Colin
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 22(2006), 18 vom: 29. Aug., Seite 7465-70
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:22
|g year:2006
|g number:18
|g day:29
|g month:08
|g pages:7465-70
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