Micellization and drug solubilization in aqueous solutions of a diblock copolymer of ethylene oxide and phenyl glycidyl ether

The aim of this study was to define a block copolymer micellar system with a high solubilization capacity for poorly soluble aromatic drugs. Ethylene oxide and phenyl glycidyl ether were sequentially polymerized to form the diblock copolymer G5E67 (G = phenyl glycidyl ether, OCH2CH(CH2OC6H5); E = ox...

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Bibliographische Detailangaben
Veröffentlicht in:	Langmuir : the ACS journal of surfaces and colloids. - 1992. - 22(2006), 18 vom: 29. Aug., Seite 7465-70
1. Verfasser:	Taboada, Pablo (VerfasserIn)
Weitere Verfasser:	Velasquez, Gemma, Barbosa, Silvia, Yang, Zhuo, Nixon, S Keith, Zhou, Zhengyuan, Heatley, Frank, Ashford, Marianne, Mosquera, Victor, Attwood, David, Booth, Colin
Format:	Aufsatz
Sprache:	English
Veröffentlicht:	2006
Zugriff auf das übergeordnete Werk:	Langmuir : the ACS journal of surfaces and colloids
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't Gels Micelles Pharmaceutical Preparations Phenyl Ethers Polymers Solutions Water 059QF0KO0R mehr... phenylglycidyl ether 44KJQ1655I Ethylene Oxide JJH7GNN18P

Beschreibung
Zusammenfassung:	The aim of this study was to define a block copolymer micellar system with a high solubilization capacity for poorly soluble aromatic drugs. Ethylene oxide and phenyl glycidyl ether were sequentially polymerized to form the diblock copolymer G5E67 (G = phenyl glycidyl ether, OCH2CH(CH2OC6H5); E = oxyethylene, OCH2CH2; subscripts denote number-average block lengths in repeat units). The association properties in aqueous solution over the range 20-50 degrees C were investigated by surface tensiometry and light scattering, yielding values of the cmc, hydrodynamic radius, and association number; gel boundaries in concentrated micellar solution were investigated by tube inversion. The solubilization capacity of G5E67 for the poorly water-soluble drug griseofulvin was higher than that of a triblock EGE copolymer of longer G block length and considerably higher than that achieved with poloxamers (EmPnEm, P = oxypropylene)
Beschreibung:	Date Completed 21.09.2007 Date Revised 19.11.2015 published: Print Citation Status MEDLINE
ISSN:	1520-5827