|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
NLM164570209 |
| 003 |
DE-627 |
| 005 |
20250207124432.0 |
| 007 |
tu |
| 008 |
231223s2006 xx ||||| 00| ||chi c |
| 028 |
5 |
2 |
|a pubmed25n0549.xml
|
| 035 |
|
|
|a (DE-627)NLM164570209
|
| 035 |
|
|
|a (NLM)16887060
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a chi
|
| 100 |
1 |
|
|a Zhang, De-ping
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Effect of interferon-gamma on bleomycin induced pulmonary fibrosis in rats
|
| 264 |
|
1 |
|c 2006
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
|
| 338 |
|
|
|a Band
|b nc
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 07.12.2010
|
| 500 |
|
|
|a Date Revised 04.08.2006
|
| 500 |
|
|
|a published: Print
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a OBJECTIVE: To observe the effects of interferon-gamma (IFN-gamma) on lung injury induced by bleomycin and its mechanism
|
| 520 |
|
|
|a METHODS: Sixty-six SD rats were randomly divided into three group: the normal control group (group N, n=24), the bleomycin group (group B, n=24) and IFN-gamma treatment group (group I, n=18). The degree of lung injury and the concentrations of tumor necrosis factor-alpha (TNF-alpha) and IFN-gamma in bronchoalveolar lavage fluid (BALF) and serum were measured
|
| 520 |
|
|
|a RESULTS: The degree of lung injury in group I was severer than group B, but with no significant difference. The concentration of TNF-alpha in BALF on 17, 21, 28 days and in serum on 21 and 28 days were significantly increased after IFN-gamma administration compared with group N and group B (all P<0.05). The concentration of IFN-gamma in BALF and serum increased on 21 and 28 days in group I (all P<0.05)
|
| 520 |
|
|
|a CONCLUSION: IFN-gamma might aggravate lung injury induced by bleomycin, and it might attribute to an increase in TNF-alpha
|
| 650 |
|
4 |
|a English Abstract
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
7 |
|a Tumor Necrosis Factor-alpha
|2 NLM
|
| 650 |
|
7 |
|a Bleomycin
|2 NLM
|
| 650 |
|
7 |
|a 11056-06-7
|2 NLM
|
| 650 |
|
7 |
|a Interferon-gamma
|2 NLM
|
| 650 |
|
7 |
|a 82115-62-6
|2 NLM
|
| 700 |
1 |
|
|a Qiu, Hui
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Zhuang, Yi
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Meng, Fan-qing
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 18(2006), 8 vom: 04. Aug., Seite 479-81
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
|
| 773 |
1 |
8 |
|g volume:18
|g year:2006
|g number:8
|g day:04
|g month:08
|g pages:479-81
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 18
|j 2006
|e 8
|b 04
|c 08
|h 479-81
|