Effect of interferon-gamma on bleomycin induced pulmonary fibrosis in rats
OBJECTIVE: To observe the effects of interferon-gamma (IFN-gamma) on lung injury induced by bleomycin and its mechanism
| Veröffentlicht in: | Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. - 1998. - 18(2006), 8 vom: 04. Aug., Seite 479-81 |
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| Weitere Verfasser: | , , |
| Format: | Aufsatz |
| Sprache: | Chinese |
| Veröffentlicht: |
2006
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| Zugriff auf das übergeordnete Werk: | Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue |
| Schlagworte: | English Abstract Journal Article Research Support, Non-U.S. Gov't Tumor Necrosis Factor-alpha Bleomycin 11056-06-7 Interferon-gamma 82115-62-6 |
| Zusammenfassung: | OBJECTIVE: To observe the effects of interferon-gamma (IFN-gamma) on lung injury induced by bleomycin and its mechanism METHODS: Sixty-six SD rats were randomly divided into three group: the normal control group (group N, n=24), the bleomycin group (group B, n=24) and IFN-gamma treatment group (group I, n=18). The degree of lung injury and the concentrations of tumor necrosis factor-alpha (TNF-alpha) and IFN-gamma in bronchoalveolar lavage fluid (BALF) and serum were measured RESULTS: The degree of lung injury in group I was severer than group B, but with no significant difference. The concentration of TNF-alpha in BALF on 17, 21, 28 days and in serum on 21 and 28 days were significantly increased after IFN-gamma administration compared with group N and group B (all P<0.05). The concentration of IFN-gamma in BALF and serum increased on 21 and 28 days in group I (all P<0.05) CONCLUSION: IFN-gamma might aggravate lung injury induced by bleomycin, and it might attribute to an increase in TNF-alpha |
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| Beschreibung: | Date Completed 07.12.2010 Date Revised 04.08.2006 published: Print Citation Status MEDLINE |
| ISSN: | 1003-0603 |