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01000naa a22002652 4500 |
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NLM162942419 |
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DE-627 |
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20231223095305.0 |
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tu |
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231223s2006 xx ||||| 00| ||eng c |
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|a pubmed24n0543.xml
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|a (DE-627)NLM162942419
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|a (NLM)16713741
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Xu, Zhiwei
|e verfasserin
|4 aut
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| 245 |
1 |
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|a STAT4 deficiency reduces autoantibody production and glomerulonephritis in a mouse model of lupus
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| 264 |
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|c 2006
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 07.09.2006
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|a Date Revised 14.11.2007
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a To determine the respective role of the IL-12 and IL-4 pathways in the pathogenesis of systemic lupus erythematosus, we bred the Stat4 and Stat6 null alleles onto the lupus-prone mouse B6.TC, which is a congenic derivative of NZM2410. This model is characterized by abnormal splenocyte expansion, distribution and architecture, T cell activation, peripheral B cell development, production of anti-nuclear antibodies, and proliferative glomerulonephritis. STAT4 deficiency normalized the expression of each of these disease markers toward or to C57BL/6 levels. In contrast, STAT6 deficiency impacted splenocyte expansion and architecture, T cell activation, and anti-nuclear autoantibody production, but without any significant effect on B cell development or renal pathology. These results show that the IL-12/STAT4 pathway is involved in multiple disease-associated phenotypes in the B6.TC mouse. In contrast, the IL-4/STAT6 pathway regulates only a subset of disease markers that did not affect renal pathology
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| 650 |
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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| 650 |
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|a Autoantibodies
|2 NLM
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| 650 |
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|a Cytokines
|2 NLM
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| 650 |
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|a STAT4 Transcription Factor
|2 NLM
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| 650 |
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|a STAT6 Transcription Factor
|2 NLM
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| 700 |
1 |
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|a Duan, Biyan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Croker, Byron P
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Morel, Laurence
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 120(2006), 2 vom: 14. Aug., Seite 189-98
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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|g volume:120
|g year:2006
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|g day:14
|g month:08
|g pages:189-98
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