STAT4 deficiency reduces autoantibody production and glomerulonephritis in a mouse model of lupus
To determine the respective role of the IL-12 and IL-4 pathways in the pathogenesis of systemic lupus erythematosus, we bred the Stat4 and Stat6 null alleles onto the lupus-prone mouse B6.TC, which is a congenic derivative of NZM2410. This model is characterized by abnormal splenocyte expansion, dis...
| Publié dans: | Clinical immunology (Orlando, Fla.). - 1999. - 120(2006), 2 vom: 14. Aug., Seite 189-98 |
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| Auteur principal: | |
| Autres auteurs: | , , |
| Format: | Article |
| Langue: | English |
| Publié: |
2006
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| Accès à la collection: | Clinical immunology (Orlando, Fla.) |
| Sujets: | Journal Article Research Support, N.I.H., Extramural Autoantibodies Cytokines STAT4 Transcription Factor STAT6 Transcription Factor |