|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
NLM162308817 |
| 003 |
DE-627 |
| 005 |
20250207070729.0 |
| 007 |
tu |
| 008 |
231223s2006 xx ||||| 00| ||chi c |
| 028 |
5 |
2 |
|a pubmed25n0541.xml
|
| 035 |
|
|
|a (DE-627)NLM162308817
|
| 035 |
|
|
|a (NLM)16647008
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a chi
|
| 100 |
1 |
|
|a Wang, Guo-xing
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Protective effects of dexamethasone on myocardium in rats with sepsis
|
| 264 |
|
1 |
|c 2006
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
|
| 338 |
|
|
|a Band
|b nc
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 05.01.2010
|
| 500 |
|
|
|a Date Revised 21.11.2013
|
| 500 |
|
|
|a published: Print
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a OBJECTIVE: To investigate the changes in heart function and myocardial mechanics in murine sepsis model, and the mechanism of the protective effect of dexamethasone on heart
|
| 520 |
|
|
|a METHODS: Wistar rats were randomly divided into control group, lipopolysaccharide (LPS) group (4 mg/kg LPS intravenously), LPS+dexamethasone group (4 mg/kg LPS+2 mg/kg dexamethasone intravenously), with 32 rats in each group. A catheter was passed through right common carotid artery to the left cardiac ventricle. Function of the left ventricle was monitored, and blood was drawn at 0, 2, 4, 6 hours to detect concentrations of tumor necrosis factor-alpha (TNF-alpha), troponin T (TnT), with 8 rats for each time point
|
| 520 |
|
|
|a RESULTS: In sepsis rats, TnT increased significantly and could be lowered by dexamethasone [at 6 hours after the treatment (1.76+/-0.57) microg/L vs. (0.70+/-0.36) microg/L, P<0.01]. There were changes in left ventricular peak systolic pressure (LVPP) and maximum rate of intraventricular pressure rise/down (+/-dp/dt max) to certain extent, and increase in left ventricular end-diastolic pressure (LVEDP), but these changes could be ameliorated by using dexamethasone. TNF-alpha increased significantly in sepsis rats, but dexamethasone could lower its level [at 2 hours after the treatment (11.22+/-2.38) pmol/L vs. (7.62+/-3.21) pmol/L, P<0.01]
|
| 520 |
|
|
|a CONCLUSION: Myocardium is remarkably damaged in rats with sepsis. TNF-alpha could be regarded as one of the factors which could produce injury to myocardium. Dexamethasone could alleviate cardiac damage produced by endotoxin in sepsis model
|
| 650 |
|
4 |
|a English Abstract
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
7 |
|a Troponin T
|2 NLM
|
| 650 |
|
7 |
|a Tumor Necrosis Factor-alpha
|2 NLM
|
| 650 |
|
7 |
|a Dexamethasone
|2 NLM
|
| 650 |
|
7 |
|a 7S5I7G3JQL
|2 NLM
|
| 700 |
1 |
|
|a Shen, Lu-hua
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Xie, Miao-rong
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Jin, Ming
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Long, Wei
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Yin, Cheng-hong
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Zhang, Shu-wen
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 18(2006), 4 vom: 29. Apr., Seite 206-9
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
|
| 773 |
1 |
8 |
|g volume:18
|g year:2006
|g number:4
|g day:29
|g month:04
|g pages:206-9
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 18
|j 2006
|e 4
|b 29
|c 04
|h 206-9
|