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231223s2006 xx ||||| 00| ||eng c |
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|a (NLM)16303333
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Laudanski, Krzysztof
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Simultaneous aberrations in Mphi and T cell function adversely affect trauma patients' clinical outcome
|b a possible faulty IL-13 feedback loop
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| 264 |
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1 |
|c 2006
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 30.03.2006
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| 500 |
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|a Date Revised 14.11.2007
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| 500 |
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Possible defective trauma patients' Mphi-T-cell feedback interactions between T cell IL-13 production and IL-1beta and IL-18 Mphi secretion were assessed. Mphi produced IL-1 and IL-18 augment T cell IL-13, which in turn limits excessive macrophage activation. Immunodepressed patients' T cells (depressed proliferation to alphaCD3 + alphaCD4) had decreased IL-13 production concomitant to aberrant Mphi activities ( upward arrow mTNFalpha, downward arrow IL-10) and consequent multiple organ failure (MOF). Decreased IL-13 levels in patients' T cell and diminished Mphi supernatant augmentation of healthy controls' T cell IL-13 production appeared concomitantly, suggesting patients' aberrant monokine levels might intensify in vivo T cell dysfunction severity. Patients' Mphi supernatants, which failed to augment controls' T cell IL-13 production, had depressed IL-1beta and lower induction of IL-18 than immunocompetent patients' Mphi, but combined addition of IL-1beta and IL-18 restored these Mphis' IL-13 enhancing activity. These data suggest that immunodepressed patients' aberrant monokine and depressed T cell IL-13 production are independent but synergistic contributors to emergence of MOF
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| 650 |
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|a Journal Article
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| 650 |
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4 |
|a Research Support, N.I.H., Extramural
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| 650 |
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7 |
|a IL13RA1 protein, human
|2 NLM
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| 650 |
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7 |
|a Interleukin-13
|2 NLM
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| 650 |
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7 |
|a Interleukin-13 Receptor alpha1 Subunit
|2 NLM
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| 650 |
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7 |
|a Monokines
|2 NLM
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| 650 |
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7 |
|a Receptors, Interleukin
|2 NLM
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| 650 |
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7 |
|a Receptors, Interleukin-13
|2 NLM
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| 700 |
1 |
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|a De, Asit
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pellegrini, Joanmarie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Miller-Graziano, Carol
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 118(2006), 2-3 vom: 15. Feb., Seite 332-41
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:118
|g year:2006
|g number:2-3
|g day:15
|g month:02
|g pages:332-41
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|a AR
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| 952 |
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|d 118
|j 2006
|e 2-3
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|c 02
|h 332-41
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