Simultaneous aberrations in Mphi and T cell function adversely affect trauma patients' clinical outcome a possible faulty IL-13 feedback loop

Simultaneous aberrations in Mphi and T cell function adversely affect trauma patients' clinical outcome : a possible faulty IL-13 feedback loop

Possible defective trauma patients' Mphi-T-cell feedback interactions between T cell IL-13 production and IL-1beta and IL-18 Mphi secretion were assessed. Mphi produced IL-1 and IL-18 augment T cell IL-13, which in turn limits excessive macrophage activation. Immunodepressed patients' T ce...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 118(2006), 2-3 vom: 15. Feb., Seite 332-41
1. Verfasser: Laudanski, Krzysztof (VerfasserIn)
Weitere Verfasser: De, Asit, Pellegrini, Joanmarie, Miller-Graziano, Carol
Format: Aufsatz
Sprache:English
Veröffentlicht: 2006
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural IL13RA1 protein, human Interleukin-13 Interleukin-13 Receptor alpha1 Subunit Monokines Receptors, Interleukin Receptors, Interleukin-13
Beschreibung
Zusammenfassung:Possible defective trauma patients' Mphi-T-cell feedback interactions between T cell IL-13 production and IL-1beta and IL-18 Mphi secretion were assessed. Mphi produced IL-1 and IL-18 augment T cell IL-13, which in turn limits excessive macrophage activation. Immunodepressed patients' T cells (depressed proliferation to alphaCD3 + alphaCD4) had decreased IL-13 production concomitant to aberrant Mphi activities ( upward arrow mTNFalpha, downward arrow IL-10) and consequent multiple organ failure (MOF). Decreased IL-13 levels in patients' T cell and diminished Mphi supernatant augmentation of healthy controls' T cell IL-13 production appeared concomitantly, suggesting patients' aberrant monokine levels might intensify in vivo T cell dysfunction severity. Patients' Mphi supernatants, which failed to augment controls' T cell IL-13 production, had depressed IL-1beta and lower induction of IL-18 than immunocompetent patients' Mphi, but combined addition of IL-1beta and IL-18 restored these Mphis' IL-13 enhancing activity. These data suggest that immunodepressed patients' aberrant monokine and depressed T cell IL-13 production are independent but synergistic contributors to emergence of MOF
Beschreibung:Date Completed 30.03.2006
Date Revised 14.11.2007
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035