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231223s2005 xx ||||| 00| ||eng c |
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|a pubmed24n0530.xml
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|a (DE-627)NLM158915364
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|a (NLM)16285824
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Carstens, Myrra G
|e verfasserin
|4 aut
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| 245 |
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|a Poly(ethylene glycol)--oligolactates with monodisperse hydrophobic blocks
|b preparation, characterization, and behavior in water
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|c 2005
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 05.04.2007
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|a Date Revised 15.11.2005
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|a published: Print
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|a Citation Status PubMed-not-MEDLINE
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|a Methoxypoly(ethylene glycol)-b-oligo-L-lactate (mPEG-b-OLA) diblock oligomers with monodisperse OLA blocks were obtained by fractionation of polydisperse block oligomers using preparative HPLC. The fractionated oligomers were composed of an mPEG block with a molecular weight of 350, 550, or 750 and an OLA block with a degree of polymerization of 4, 6, 8, or 10. The diblock oligomers with a low PEG content were fully amorphous, with glass transition temperatures ranging from -60 to -20 degrees C, indicating that the blocks were miscible. Upon heating aqueous dispersions of the block oligomers, cloud points, depending on the PEG/OLA ratio of the block oligomer, were observed at temperatures above 40 degrees C. The monodispersity of the hydrophobic block enabled the amphiphilic molecules to form nanoparticles in water with a hydrodynamic radius of 130-300 nm, at concentrations above the critical aggregation concentration (0.4-1 mg/mL), whereas polydisperse mPEG-b-OLAs gave formation of large aggregates. Static light scattering measurements showed that the nanoparticles have a low density (0.6-25 mg/mL), indicating that the particles are highly hydrated. In agreement herewith, the (1)H NMR spectra of nanoparticles in D2O closely resembled spectra in a good solvent for both blocks (CDCl3). It is therefore suggested that the nanoparticles contain a hydrated core of mPEG-b-OLA block oligomers, stabilized by a thin outer PEG layer. The particles were stable for two weeks, except for the mPEG350 series and mPEG750-b-OLA4, indicating that both the PEG block size and the PEG weight fraction of the oligomers determine their stability. The evident self-emulsifying properties of mPEG-b-oligo-l-lactates with monodisperse hydrophobic blocks as demonstrated in this study, together with their expected biocompatibility and biodegradability, make these systems well suitable for pharmaceutical applications
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|a Journal Article
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|a van Nostrum, Cornelus F
|e verfasserin
|4 aut
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| 700 |
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|a Ramzi, Aissa
|e verfasserin
|4 aut
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| 700 |
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|a Meeldijk, Johannes D
|e verfasserin
|4 aut
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| 700 |
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|a Verrijk, Ruud
|e verfasserin
|4 aut
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| 700 |
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|a de Leede, Leo L
|e verfasserin
|4 aut
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| 700 |
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|a Crommelin, Daan J A
|e verfasserin
|4 aut
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| 700 |
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|a Hennink, Wim E
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 21(2005), 24 vom: 22. Nov., Seite 11446-54
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:21
|g year:2005
|g number:24
|g day:22
|g month:11
|g pages:11446-54
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| 951 |
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|a AR
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| 952 |
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|d 21
|j 2005
|e 24
|b 22
|c 11
|h 11446-54
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