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01000caa a22002652 4500 |
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NLM15743849X |
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DE-627 |
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| 007 |
tu |
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231223s2005 xx ||||| 00| ||eng c |
| 028 |
5 |
2 |
|a pubmed25n0525.xml
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|a (DE-627)NLM15743849X
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| 035 |
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|a (NLM)16126005
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Zhuang, Haoyang
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Association of anti-nucleoprotein autoantibodies with upregulation of Type I interferon-inducible gene transcripts and dendritic cell maturation in systemic lupus erythematosus
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| 264 |
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1 |
|c 2005
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 16.02.2006
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| 500 |
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|a Date Revised 14.12.2020
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| 500 |
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|a published: Print-Electronic
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a Lupus patients selectively produce autoantibodies against nucleoproteins. Since the RNA/DNA components of these autoantigens are endogenous TLR ligands capable of stimulating Type I interferon (IFN-I) production, we asked whether autoantibodies against the ribonucleoproteins Sm/RNP and Ro60 and double-stranded DNA are associated with high levels of IFN-I. IFN-I levels were increased in SLE (n = 88) vs. other autoimmune diseases (n = 82) and controls (n = 57) (P < 0.0001) and were associated positively with autoantibodies against Sm/RNP, Ro60/La, and dsDNA but negatively with anti-phospholipid. Low numbers of circulating plasmacytoid and myeloid dendritic cells also were associated with these autoantibodies. The IFN-I and dendritic cell abnormalities correlated with disease severity and were not therapy-related. These findings suggest that immunostimulatory nucleic acid components of autoantigens may act as endogenous adjuvants by promoting IFN-I production and dendritic cell maturation, helping to explain the high prevalence of autoantibodies against nucleoprotein antigens in SLE
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, N.I.H., Extramural
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| 650 |
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7 |
|a Antibodies, Antinuclear
|2 NLM
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| 650 |
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7 |
|a Autoantigens
|2 NLM
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| 650 |
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7 |
|a Interferon Type I
|2 NLM
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| 650 |
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7 |
|a Interferon-alpha
|2 NLM
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| 650 |
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7 |
|a Myxovirus Resistance Proteins
|2 NLM
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| 650 |
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7 |
|a RNA, Small Cytoplasmic
|2 NLM
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| 650 |
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7 |
|a RO60 protein, human
|2 NLM
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| 650 |
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7 |
|a Ribonucleoproteins
|2 NLM
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| 650 |
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7 |
|a DNA
|2 NLM
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| 650 |
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7 |
|a 9007-49-2
|2 NLM
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| 650 |
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7 |
|a GTP-Binding Proteins
|2 NLM
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| 650 |
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7 |
|a EC 3.6.1.-
|2 NLM
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| 700 |
1 |
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|a Narain, Sonali
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sobel, Eric
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lee, Pui Y
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nacionales, Dina C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kelly, Kindra M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Richards, Hanno B
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Segal, Mark
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Stewart, Carol
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Satoh, Minoru
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Reeves, Westley H
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 117(2005), 3 vom: 15. Dez., Seite 238-50
|w (DE-627)NLM098196855
|x 1521-6616
|7 nnns
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| 773 |
1 |
8 |
|g volume:117
|g year:2005
|g number:3
|g day:15
|g month:12
|g pages:238-50
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 117
|j 2005
|e 3
|b 15
|c 12
|h 238-50
|