Association of anti-nucleoprotein autoantibodies with upregulation of Type I interferon-inducible gene transcripts and dendritic cell maturation in systemic lupus erythematosus

Association of anti-nucleoprotein autoantibodies with upregulation of Type I interferon-inducible gene transcripts and dendritic cell maturation in systemic lupus erythematosus

Lupus patients selectively produce autoantibodies against nucleoproteins. Since the RNA/DNA components of these autoantigens are endogenous TLR ligands capable of stimulating Type I interferon (IFN-I) production, we asked whether autoantibodies against the ribonucleoproteins Sm/RNP and Ro60 and doub...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 117(2005), 3 vom: 15. Dez., Seite 238-50
1. Verfasser: Zhuang, Haoyang (VerfasserIn)
Weitere Verfasser: Narain, Sonali, Sobel, Eric, Lee, Pui Y, Nacionales, Dina C, Kelly, Kindra M, Richards, Hanno B, Segal, Mark, Stewart, Carol, Satoh, Minoru, Reeves, Westley H
Format: Aufsatz
Sprache:English
Veröffentlicht: 2005
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Antibodies, Antinuclear Autoantigens Interferon Type I Interferon-alpha Myxovirus Resistance Proteins RNA, Small Cytoplasmic RO60 protein, human Ribonucleoproteins mehr... DNA 9007-49-2 GTP-Binding Proteins EC 3.6.1.-