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01000caa a22002652 4500 |
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NLM156783711 |
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DE-627 |
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tu |
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231223s2005 xx ||||| 00| ||eng c |
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2 |
|a pubmed25n0523.xml
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|a (DE-627)NLM156783711
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| 035 |
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|a (NLM)16043414
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| 040 |
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Wei, Chi-Chen
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Detection of IL-20 and its receptors on psoriatic skin
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| 264 |
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1 |
|c 2005
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 27.10.2005
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| 500 |
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|a Date Revised 11.12.2018
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| 500 |
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|a published: Print
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a The aim of this study was to investigate the expression of interleukin-20 (IL-20) and its receptors on psoriatic skin by immunohistochemical analysis and to evaluate the correlation of CD8-positive T lymphocytes with epidermal proliferation. Overexpression of IL-20 and its receptors was detected in the keratinocytes of the lesional skin of psoriasis and spongiotic dermatitis. The expression pattern of IL-20 spreads throughout the whole layer of epidermis, while IL-19 was expressed in up to three or four layers suprabasally. The serum level of IL-20 in psoriatic patients was significantly lower than that in healthy controls. IL-20 upregulated KGF transcripts on CD8-positive T cells. We hypothesize that overexpression of IL-20 is correlated with keratinocyte proliferation that acts through their receptor complex expressed by keratinocytes themselves. Furthermore, IL-20 can stimulate CD8-positive lymphocytes to produce KGF, which may contribute to sustaining the hyperproliferative status of the keratinocytes
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a FGF7 protein, human
|2 NLM
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| 650 |
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7 |
|a IL19 protein, human
|2 NLM
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| 650 |
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7 |
|a Interleukins
|2 NLM
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| 650 |
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7 |
|a Receptors, Interleukin
|2 NLM
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| 650 |
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7 |
|a interleukin-20 receptor
|2 NLM
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| 650 |
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7 |
|a Fibroblast Growth Factor 7
|2 NLM
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| 650 |
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7 |
|a 126469-10-1
|2 NLM
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| 650 |
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7 |
|a Interleukin-10
|2 NLM
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| 650 |
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7 |
|a 130068-27-8
|2 NLM
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| 650 |
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7 |
|a Fibroblast Growth Factors
|2 NLM
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| 650 |
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7 |
|a 62031-54-3
|2 NLM
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| 650 |
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7 |
|a interleukin 20
|2 NLM
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| 650 |
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7 |
|a U91R7IMG8U
|2 NLM
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| 700 |
1 |
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|a Chen, Wei-Yu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Yo-Ching
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Po-Jen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lee, Julia Yu-Yun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wong, Tak-Wah
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Wen Chieh
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Jen-Chin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Guan-Ying
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chang, Ming-Shi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lin, Yu-Chih
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 117(2005), 1 vom: 15. Okt., Seite 65-72
|w (DE-627)NLM098196855
|x 1521-6616
|7 nnns
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| 773 |
1 |
8 |
|g volume:117
|g year:2005
|g number:1
|g day:15
|g month:10
|g pages:65-72
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 117
|j 2005
|e 1
|b 15
|c 10
|h 65-72
|