Detection of IL-20 and its receptors on psoriatic skin
The aim of this study was to investigate the expression of interleukin-20 (IL-20) and its receptors on psoriatic skin by immunohistochemical analysis and to evaluate the correlation of CD8-positive T lymphocytes with epidermal proliferation. Overexpression of IL-20 and its receptors was detected in...
| Publié dans: | Clinical immunology (Orlando, Fla.). - 1999. - 117(2005), 1 vom: 15. Okt., Seite 65-72 |
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| Auteur principal: | |
| Autres auteurs: | , , , , , , , , , |
| Format: | Article |
| Langue: | English |
| Publié: |
2005
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| Accès à la collection: | Clinical immunology (Orlando, Fla.) |
| Sujets: | Journal Article Research Support, Non-U.S. Gov't FGF7 protein, human IL19 protein, human Interleukins Receptors, Interleukin interleukin-20 receptor Fibroblast Growth Factor 7 126469-10-1 Interleukin-10 plus... |
| Résumé: | The aim of this study was to investigate the expression of interleukin-20 (IL-20) and its receptors on psoriatic skin by immunohistochemical analysis and to evaluate the correlation of CD8-positive T lymphocytes with epidermal proliferation. Overexpression of IL-20 and its receptors was detected in the keratinocytes of the lesional skin of psoriasis and spongiotic dermatitis. The expression pattern of IL-20 spreads throughout the whole layer of epidermis, while IL-19 was expressed in up to three or four layers suprabasally. The serum level of IL-20 in psoriatic patients was significantly lower than that in healthy controls. IL-20 upregulated KGF transcripts on CD8-positive T cells. We hypothesize that overexpression of IL-20 is correlated with keratinocyte proliferation that acts through their receptor complex expressed by keratinocytes themselves. Furthermore, IL-20 can stimulate CD8-positive lymphocytes to produce KGF, which may contribute to sustaining the hyperproliferative status of the keratinocytes |
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| Description: | Date Completed 27.10.2005 Date Revised 11.12.2018 published: Print Citation Status MEDLINE |
| ISSN: | 1521-6616 |