IA-2 combined epitope assay a new, highly sensitive approach to evaluate IA-2 humoral autoimmunity in type 1 diabetes

IA-2 combined epitope assay : a new, highly sensitive approach to evaluate IA-2 humoral autoimmunity in type 1 diabetes

Islet tyrosine phosphatase 2 (IA-2) is one of the major autoantigens in type 1 diabetes. The aim of this work was to evaluate which IA-2 construct(s) among those usually employed has the highest sensitivity and specificity for detecting IA-2 autoantibodies in autoimmune diabetes and whether the comb...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 115(2005), 3 vom: 31. Juni, Seite 260-7
1. Verfasser: Tiberti, Claudio (VerfasserIn)
Weitere Verfasser: Verrienti, Antonella, Fiore, Benedetta, Yu, Liping, Eisenbarth, George S, Dotta, Francesco, Di Mario, Umberto
Format: Aufsatz
Sprache:English
Veröffentlicht: 2005
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Autoantibodies Biomarkers Epitopes Membrane Proteins Protein Phosphatase 2 EC 3.1.3.16 mehr... PTPRN2 protein, human EC 3.1.3.48 Protein Tyrosine Phosphatase, Non-Receptor Type 1 Protein Tyrosine Phosphatases Receptor-Like Protein Tyrosine Phosphatases, Class 8