Circulating Valpha24+Vbeta11+ NKT cell numbers and dendritic cell CD1d expression in hepatitis C virus infected patients

CD1d-restricted natural killer T (NKT) cells are involved in the regulation of various immune responses, and have been shown to inhibit viral replication in animal hepatitis models when activated by the glycolipid alpha-galactosylceramide (alpha-GalCer, KRN7000). Previous studies have indicated that...

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Bibliographische Detailangaben
Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 114(2005), 2 vom: 10. Feb., Seite 183-9
1. Verfasser:	van der Vliet, Hans J J (VerfasserIn)
Weitere Verfasser:	Molling, Johan W, von Blomberg, B Mary E, Kölgen, Wendy, Stam, Anita G, de Gruijl, Tanja D, Mulder, Chris J, Janssen, Harry L A, Nishi, Nobusuke, van den Eertwegh, Alfons J M, Scheper, Rik J, van Nieuwkerk, Carin J M
Format:	Aufsatz
Sprache:	English
Veröffentlicht:	2005
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't Antigens, CD1 Antigens, CD1d Antiviral Agents CD1D protein, human Interferon alpha-2 Interferon-alpha RNA, Viral Recombinant Proteins mehr... Polyethylene Glycols 3WJQ0SDW1A Ribavirin 49717AWG6K peginterferon alfa-2b G8RGG88B68

Beschreibung
Zusammenfassung:	CD1d-restricted natural killer T (NKT) cells are involved in the regulation of various immune responses, and have been shown to inhibit viral replication in animal hepatitis models when activated by the glycolipid alpha-galactosylceramide (alpha-GalCer, KRN7000). Previous studies have indicated that alpha-GalCer-induced activation of the immune system requires both CD1d expression by antigen-presenting cells as well as (normal) numbers of NKT cells. Discrepancies exist over circulating numbers of human invariant Valpha24+Vbeta11+ NKT cells during hepatitis C virus (HCV) infection. Here, by cross-sectional analysis and longitudinal analysis of patients undergoing effective combination antiviral therapy, we demonstrate that circulating Valpha24+Vbeta11+ NKT cell numbers are not decreased during active HCV infection. Importantly, as we also show that CD1d is expressed at comparable levels by peripheral blood monocytes and CD1c+ myeloid dendritic cells (DC) of healthy individuals and HCV-infected patients, these data indicate that all ingredients for evaluating the antiviral effects of the Valpha24+Vbeta11+ NKT cell ligand alpha-GalCer in HCV-infected patients are present
Beschreibung:	Date Completed 08.03.2005 Date Revised 01.12.2018 published: Print Citation Status MEDLINE
ISSN:	1521-7035