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| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM151775206 |
| 003 |
DE-627 |
| 005 |
20231223060648.0 |
| 007 |
tu |
| 008 |
231223s2004 xx ||||| 00| ||eng c |
| 028 |
5 |
2 |
|a pubmed24n0506.xml
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| 035 |
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|a (DE-627)NLM151775206
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| 035 |
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|a (NLM)15507397
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| 040 |
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Yu, Jeesuk
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Analysis of children with type 1 diabetes in Korea
|b high prevalence of specific anti-islet autoantibodies, immunogenetic similarities to Western populations with "unique" haplotypes, and lack of discrimination by aspartic acid at position 57 of DQB
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| 264 |
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1 |
|c 2004
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 15.12.2004
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| 500 |
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|a Date Revised 21.11.2013
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| 500 |
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|a published: Print
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a This study analyzed the expression of anti-islet autoantibodies and HLA-DR and -DQ genotypes in Korean children with type 1 diabetes mellitus (T1DM). The positivity of the anti-ICA512, anti-GAD65, and anti-insulin autoantibodies in the newly onset T1DM patients (n = 15) was 66.7%, 86.7%, and 46.7%, respectively, and all of them had one or more of the autoantibodies. HLA analysis showed higher frequencies of HLA-DRB1*0301, *0405, *09012 and -DQB1*0201, *0401, *03032 alleles in T1DM patients compared to controls (P(c) < 0.05). Because HLA-DQB1*0401, *03032 alleles carry aspartic acid at position 57 of DQB, susceptibility to T1DM in Korean children was not related to the presence of aspartic acid at position 57 of DQB1 locus. We suggest this unique HLA-DR, -DQ allele distribution might be an important factor for the low incidence of T1DM in Korea, and the combined anti-islet autoantibody assays could be valuable screening markers for the early detection of T1DM in Korea
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| 650 |
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4 |
|a Comparative Study
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Autoantibodies
|2 NLM
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| 650 |
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7 |
|a HLA-DQ Antigens
|2 NLM
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| 650 |
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7 |
|a HLA-DQ beta-Chains
|2 NLM
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| 650 |
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7 |
|a HLA-DQB1 antigen
|2 NLM
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| 650 |
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7 |
|a HLA-DR Antigens
|2 NLM
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| 650 |
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7 |
|a HLA-DRB1 Chains
|2 NLM
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| 650 |
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7 |
|a HLA-DRB1*03:01 antigen
|2 NLM
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| 650 |
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7 |
|a Aspartic Acid
|2 NLM
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| 650 |
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7 |
|a 30KYC7MIAI
|2 NLM
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| 700 |
1 |
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|a Shin, Chung Ho
|e verfasserin
|4 aut
|
| 700 |
1 |
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|a Yang, Sei Won
|e verfasserin
|4 aut
|
| 700 |
1 |
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|a Park, Myoung Hee
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Eisenbarth, George S
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 113(2004), 3 vom: 12. Dez., Seite 318-25
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:113
|g year:2004
|g number:3
|g day:12
|g month:12
|g pages:318-25
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
|
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|a GBV_ILN_350
|
| 951 |
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|a AR
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| 952 |
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|d 113
|j 2004
|e 3
|b 12
|c 12
|h 318-25
|